ID   GNGF_STRP8              Reviewed;         325 AA.
AC   Q8P1T7;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Putative gluconeogenesis factor {ECO:0000255|HAMAP-Rule:MF_00973};
GN   OrderedLocusNames=spyM18_0714;
OS   Streptococcus pyogenes serotype M18 (strain MGAS8232).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=186103;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGAS8232;
RX   PubMed=11917108; DOI=10.1073/pnas.062526099;
RA   Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S.,
RA   Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D.,
RA   Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A.,
RA   Veasy L.G., Musser J.M.;
RT   "Genome sequence and comparative microarray analysis of serotype M18 group
RT   A Streptococcus strains associated with acute rheumatic fever outbreaks.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002).
CC   -!- FUNCTION: Required for morphogenesis under gluconeogenic growth
CC       conditions. {ECO:0000255|HAMAP-Rule:MF_00973}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00973}.
CC   -!- SIMILARITY: Belongs to the gluconeogenesis factor family.
CC       {ECO:0000255|HAMAP-Rule:MF_00973}.
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DR   EMBL; AE009949; AAL97385.1; -; Genomic_DNA.
DR   RefSeq; WP_011017561.1; NC_003485.1.
DR   AlphaFoldDB; Q8P1T7; -.
DR   SMR; Q8P1T7; -.
DR   KEGG; spm:spyM18_0714; -.
DR   HOGENOM; CLU_044041_0_1_9; -.
DR   OMA; LCGDDDW; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043743; F:LPPG:FO 2-phospho-L-lactate transferase activity; IEA:InterPro.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.10680; -; 1.
DR   HAMAP; MF_00973; Gluconeogen_factor; 1.
DR   InterPro; IPR002882; CofD.
DR   InterPro; IPR038136; CofD-like_dom_sf.
DR   InterPro; IPR010119; Gluconeogen_factor.
DR   PANTHER; PTHR30135; PTHR30135; 1.
DR   Pfam; PF01933; CofD; 1.
DR   SUPFAM; SSF142338; SSF142338; 1.
DR   TIGRFAMs; TIGR01826; CofD_related; 1.
PE   3: Inferred from homology;
KW   Cytoplasm.
FT   CHAIN           1..325
FT                   /note="Putative gluconeogenesis factor"
FT                   /id="PRO_0000107817"
SQ   SEQUENCE   325 AA;  35737 MW;  E751456F26202851 CRC64;
     MKNPKMTVIG GGTGISIILK SLRNEAVDIT AVVTVADDGG SSGELRNAMQ LAPPGDLRNV
     LLAMSDMPKF YERVFQYRFN ESDGALAGHP LGNLIIAGIS EMQGSTYNAI QILTKFFHIT
     GKIYPSSEQA LTLHAVFKDG HEVAGESSIA KYQGMIDHVY VTNTYNDQKP QASRKVVEAI
     LESDMIVLGP GSLFTSILPN LVIPEIKEAL RQTKAEVVYI CNIMTQYGET EQFSDADHVA
     VLNQHLGRDL IDTVLVNVAK VPQAYMNSNK FDEYLVQVDH DFAGLCRAAK RVISSYFLRL
     ENGGAFHDGN LVVEELMNLV RIVKQ