ID   GNGF_ECOLI              Reviewed;         302 AA.
AC   P75767;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Putative gluconeogenesis factor {ECO:0000255|HAMAP-Rule:MF_00973};
GN   Name=ybhK; OrderedLocusNames=b0780, JW0763;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA   Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K.,
RA   Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S.,
RA   Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H.,
RA   Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G.,
RA   Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M.,
RA   Horiuchi T.;
RT   "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 12.7-28.0 min region on the linkage map.";
RL   DNA Res. 3:137-155(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   PUTATIVE FUNCTION.
RX   PubMed=16272399; DOI=10.1099/mic.0.28172-0;
RA   Gorke B., Foulquier E., Galinier A.;
RT   "YvcK of Bacillus subtilis is required for a normal cell shape and for
RT   growth on Krebs cycle intermediates and substrates of the pentose phosphate
RT   pathway.";
RL   Microbiology 151:3777-3791(2005).
CC   -!- FUNCTION: Required for morphogenesis under gluconeogenic growth
CC       conditions. {ECO:0000305}.
CC   -!- INTERACTION:
CC       P75767; P0AEW6: gsk; NbExp=5; IntAct=EBI-550390, EBI-548746;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00973}.
CC   -!- MISCELLANEOUS: Was shown to partially rescue a mgfK mutant in
CC       B.subtilis, suggesting that the function of this protein is conserved
CC       in different bacteria. {ECO:0000305|PubMed:16272399}.
CC   -!- SIMILARITY: Belongs to the gluconeogenesis factor family.
CC       {ECO:0000255|HAMAP-Rule:MF_00973}.
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DR   EMBL; U00096; AAC73867.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA35438.1; -; Genomic_DNA.
DR   PIR; D64814; D64814.
DR   RefSeq; NP_415301.1; NC_000913.3.
DR   RefSeq; WP_001295302.1; NZ_STEB01000028.1.
DR   AlphaFoldDB; P75767; -.
DR   SMR; P75767; -.
DR   BioGRID; 4259958; 12.
DR   BioGRID; 849765; 10.
DR   DIP; DIP-11414N; -.
DR   IntAct; P75767; 44.
DR   STRING; 511145.b0780; -.
DR   jPOST; P75767; -.
DR   PaxDb; P75767; -.
DR   PRIDE; P75767; -.
DR   EnsemblBacteria; AAC73867; AAC73867; b0780.
DR   EnsemblBacteria; BAA35438; BAA35438; BAA35438.
DR   GeneID; 66670949; -.
DR   GeneID; 945390; -.
DR   KEGG; ecj:JW0763; -.
DR   KEGG; eco:b0780; -.
DR   PATRIC; fig|1411691.4.peg.1498; -.
DR   EchoBASE; EB3431; -.
DR   eggNOG; COG0391; Bacteria.
DR   HOGENOM; CLU_044041_2_0_6; -.
DR   InParanoid; P75767; -.
DR   OMA; LCGDDDW; -.
DR   PhylomeDB; P75767; -.
DR   BioCyc; EcoCyc:G6402-MON; -.
DR   PRO; PR:P75767; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043743; F:LPPG:FO 2-phospho-L-lactate transferase activity; IEA:InterPro.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.10680; -; 1.
DR   HAMAP; MF_00973; Gluconeogen_factor; 1.
DR   InterPro; IPR002882; CofD.
DR   InterPro; IPR038136; CofD-like_dom_sf.
DR   InterPro; IPR010119; Gluconeogen_factor.
DR   PANTHER; PTHR30135; PTHR30135; 1.
DR   Pfam; PF01933; CofD; 1.
DR   SUPFAM; SSF142338; SSF142338; 1.
DR   TIGRFAMs; TIGR01826; CofD_related; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..302
FT                   /note="Putative gluconeogenesis factor"
FT                   /id="PRO_0000107797"
SQ   SEQUENCE   302 AA;  32788 MW;  4E88D67B89576874 CRC64;
     MRNRTLADLD RVVALGGGHG LGRVLSSLSS LGSRLTGIVT TTDNGGSTGR IRRSEGGIAW
     GDMRNCLNQL ITEPSVASAM FEYRFGGNGE LSGHNLGNLM LKALDHLSVR PLEAINLIRN
     LLKVDTHLIP MSEHPVDLMA IDDQGHEVYG EVNIDQLTTP IQELLLTPNV PATREAVHAI
     NEADLIIIGP GSFYTSLMPI LLLKEIAQAL RRTPAPMVYI GNLGRELSLP AANLKLESKL
     AIMEQYVGKK VIDAVIVGPK VDVSAVKERI VIQEVLEASD IPYRHDRQLL HNALEKALQA
     LG