ID   GNB5_RABIT              Reviewed;         353 AA.
AC   Q6PNB6;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Guanine nucleotide-binding protein subunit beta-5;
DE   AltName: Full=Gbeta5;
DE   AltName: Full=Transducin beta chain 5;
GN   Name=GNB5;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Zhou H.;
RT   "Molecular cloning of guanine nucletide binding protein beta 5.";
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Enhances GTPase-activating protein (GAP) activity of
CC       regulator of G protein signaling (RGS) proteins, hence involved in the
CC       termination of the signaling initiated by the G protein coupled
CC       receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha
CC       subunits, thereby promoting their inactivation (Probable). Increases
CC       RGS9 GTPase-activating protein (GAP) activity, hence contributes to the
CC       deactivation of G protein signaling initiated by D(2) dopamine
CC       receptors (By similarity). May play an important role in neuronal
CC       signaling, including in the parasympathetic, but not sympathetic,
CC       control of heart rate (By similarity). {ECO:0000250|UniProtKB:A1L271,
CC       ECO:0000250|UniProtKB:O14775, ECO:0000305}.
CC   -!- SUBUNIT: Component of a complex composed of RGS9, GNB5 and RGS9BP;
CC       within this complex, the presence of GNB5 stabilizes both itself and
CC       RGS9 and increases RGS9 GTPase-activating protein (GAP) activity (By
CC       similarity). Interacts with RGS6 and RGS7 (By similarity).
CC       {ECO:0000250|UniProtKB:O14775, ECO:0000250|UniProtKB:P62881}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P62881}.
CC   -!- SIMILARITY: Belongs to the WD repeat G protein beta family.
CC       {ECO:0000305}.
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DR   EMBL; AY591252; AAT02217.1; -; mRNA.
DR   RefSeq; NP_001075639.1; NM_001082170.1.
DR   AlphaFoldDB; Q6PNB6; -.
DR   SMR; Q6PNB6; -.
DR   STRING; 9986.ENSOCUP00000010220; -.
DR   PRIDE; Q6PNB6; -.
DR   GeneID; 100008941; -.
DR   KEGG; ocu:100008941; -.
DR   CTD; 10681; -.
DR   eggNOG; KOG0286; Eukaryota.
DR   InParanoid; Q6PNB6; -.
DR   OrthoDB; 704786at2759; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:AgBase.
DR   GO; GO:0005886; C:plasma membrane; ISS:AgBase.
DR   GO; GO:0051087; F:chaperone binding; ISS:CAFA.
DR   GO; GO:0031682; F:G-protein gamma-subunit binding; ISS:CAFA.
DR   GO; GO:0007212; P:dopamine receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:AgBase.
DR   GO; GO:1901386; P:negative regulation of voltage-gated calcium channel activity; ISS:CAFA.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR001632; Gprotein_B.
DR   InterPro; IPR016346; Guanine_nucleotide-bd_bsu.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19850; PTHR19850; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00319; GPROTEINB.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Repeat; Transducer; WD repeat.
FT   CHAIN           1..353
FT                   /note="Guanine nucleotide-binding protein subunit beta-5"
FT                   /id="PRO_0000127708"
FT   REPEAT          61..100
FT                   /note="WD 1"
FT   REPEAT          103..142
FT                   /note="WD 2"
FT   REPEAT          151..192
FT                   /note="WD 3"
FT   REPEAT          194..236
FT                   /note="WD 4"
FT   REPEAT          237..276
FT                   /note="WD 5"
FT   REPEAT          278..320
FT                   /note="WD 6"
FT   REPEAT          323..352
FT                   /note="WD 7"
SQ   SEQUENCE   353 AA;  38756 MW;  0314715E2EB1FE2B CRC64;
     MATDGLHENE TLASLKIEAE SLKGKLEEER AKLHDVELHQ VAERVEALGQ FVMKTRRTLK
     GHGNKVLCMD WCKDKRRIVS SSQDGKVIVW DSFTTNKEHA VTMPCTWVMA CAYAPSGCAI
     ACGGLDNKCS VYPLTFDKNE NMAAKKKSVA MHTNYLSACS FTNSDMQILT ASGDGTCALW
     DVESGQLLQS FHGHGADVLC LDLAPSETGN TFVSGGCDKK AMVWDMRSGQ CVQAFETHES
     DINSVRYYPS GDAFASGSDD ATCRLYDLRA DREVAIYSKE SIIFGASSVD FSLSGRLLFA
     GYNDYTINVW DVLKGARVSI LFGHENRVST LRVSPDGTAF CSGSWDHTLR VWA