GNB1L_MOUSE
ID GNB1L_MOUSE Reviewed; 326 AA.
AC Q9EQ15; Q8R1F3; Q9CWP2; Q9D3Y1;
DT 13-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 13-DEC-2002, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Guanine nucleotide-binding protein subunit beta-like protein 1;
DE Short=G protein subunit beta-like protein 1;
DE AltName: Full=WD repeat-containing protein 14;
DE AltName: Full=WD40 repeat-containing protein deleted in VCFS;
DE Short=WDVCF;
GN Name=Gnb1l; Synonyms=Estm55, Wdr14;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=11350118; DOI=10.1006/geno.2000.6506;
RA Funke B., Pandita R.K., Morrow B.E.;
RT "Isolation and characterization of a novel gene containing WD40 repeats
RT from the region deleted in velo-cardio-facial/DiGeorge syndrome on
RT chromosome 22q11.";
RL Genomics 73:264-271(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Embryonic stem cell, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=Czech II; TISSUE=Mammary tumor, and Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9EQ15-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9EQ15-2; Sequence=VSP_006769, VSP_006770;
CC -!- TISSUE SPECIFICITY: Expressed at low levels in most tissues and highly
CC expressed in adult testis.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB26980.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF301595; AAG44996.1; -; mRNA.
DR EMBL; AK010489; BAB26980.1; ALT_FRAME; mRNA.
DR EMBL; AK016952; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC024635; AAH24635.1; -; mRNA.
DR EMBL; BC037676; AAH37676.1; -; mRNA.
DR CCDS; CCDS28022.1; -. [Q9EQ15-1]
DR RefSeq; NP_001075151.1; NM_001081682.2. [Q9EQ15-1]
DR RefSeq; NP_075609.2; NM_023120.5. [Q9EQ15-1]
DR RefSeq; XP_011244133.1; XM_011245831.1. [Q9EQ15-1]
DR AlphaFoldDB; Q9EQ15; -.
DR SMR; Q9EQ15; -.
DR STRING; 10090.ENSMUSP00000130371; -.
DR iPTMnet; Q9EQ15; -.
DR PhosphoSitePlus; Q9EQ15; -.
DR EPD; Q9EQ15; -.
DR PaxDb; Q9EQ15; -.
DR PRIDE; Q9EQ15; -.
DR ProteomicsDB; 267640; -. [Q9EQ15-1]
DR ProteomicsDB; 267641; -. [Q9EQ15-2]
DR Antibodypedia; 7752; 111 antibodies from 21 providers.
DR DNASU; 13972; -.
DR Ensembl; ENSMUST00000090086; ENSMUSP00000087544; ENSMUSG00000000884. [Q9EQ15-1]
DR Ensembl; ENSMUST00000115600; ENSMUSP00000111263; ENSMUSG00000000884. [Q9EQ15-2]
DR Ensembl; ENSMUST00000231621; ENSMUSP00000156162; ENSMUSG00000000884. [Q9EQ15-1]
DR GeneID; 13972; -.
DR KEGG; mmu:13972; -.
DR UCSC; uc007yoa.2; mouse. [Q9EQ15-1]
DR CTD; 54584; -.
DR MGI; MGI:1338057; Gnb1l.
DR VEuPathDB; HostDB:ENSMUSG00000000884; -.
DR eggNOG; KOG0322; Eukaryota.
DR GeneTree; ENSGT00390000018606; -.
DR HOGENOM; CLU_041940_2_1_1; -.
DR InParanoid; Q9EQ15; -.
DR OMA; NSLCFQE; -.
DR OrthoDB; 1543596at2759; -.
DR PhylomeDB; Q9EQ15; -.
DR TreeFam; TF344050; -.
DR BioGRID-ORCS; 13972; 28 hits in 73 CRISPR screens.
DR ChiTaRS; Gnb1l; mouse.
DR PRO; PR:Q9EQ15; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q9EQ15; protein.
DR Bgee; ENSMUSG00000000884; Expressed in spermatocyte and 178 other tissues.
DR ExpressionAtlas; Q9EQ15; baseline and differential.
DR Genevisible; Q9EQ15; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0035176; P:social behavior; IMP:MGI.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 1.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..326
FT /note="Guanine nucleotide-binding protein subunit beta-like
FT protein 1"
FT /id="PRO_0000051009"
FT REPEAT 17..61
FT /note="WD 1"
FT REPEAT 64..104
FT /note="WD 2"
FT REPEAT 159..202
FT /note="WD 3"
FT REPEAT 205..244
FT /note="WD 4"
FT REPEAT 250..291
FT /note="WD 5"
FT REPEAT 292..325
FT /note="WD 6"
FT VAR_SEQ 172..198
FT /note="TNSSLRPLLLAGYEDGSVTLWDISERK -> ESQKPQCPCLNWYRRGGGKVI
FT TGYCLF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_006769"
FT VAR_SEQ 199..326
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_006770"
FT CONFLICT 2
FT /note="A -> S (in Ref. 2; BAB26980)"
FT /evidence="ECO:0000305"
FT CONFLICT 33
FT /note="A -> T (in Ref. 2; BAB26980)"
FT /evidence="ECO:0000305"
FT CONFLICT 59
FT /note="V -> I (in Ref. 2; BAB26980)"
FT /evidence="ECO:0000305"
FT CONFLICT 66
FT /note="G -> W (in Ref. 2; BAB26980)"
FT /evidence="ECO:0000305"
FT CONFLICT 80
FT /note="H -> Q (in Ref. 2; BAB26980)"
FT /evidence="ECO:0000305"
FT CONFLICT 84
FT /note="S -> T (in Ref. 2; BAB26980)"
FT /evidence="ECO:0000305"
FT CONFLICT 95
FT /note="D -> Q (in Ref. 2; BAB26980)"
FT /evidence="ECO:0000305"
FT CONFLICT 133..135
FT /note="GKG -> RKS (in Ref. 2; BAB26980)"
FT /evidence="ECO:0000305"
FT CONFLICT 139
FT /note="V -> F (in Ref. 2; BAB26980)"
FT /evidence="ECO:0000305"
FT CONFLICT 150
FT /note="V -> E (in Ref. 2; BAB26980)"
FT /evidence="ECO:0000305"
FT CONFLICT 236
FT /note="L -> Q (in Ref. 1; AAG44996)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 326 AA; 35663 MW; 64EB678A3EE72D89 CRC64;
MAALFPPPPG PRFVLRGTQS AVNTLHFCPP SQAAGNPLLF SGSQNGLVHI WSLQTRRIVT
TLNGHGGQGV IWLKTLPQGH QLLSQGRDLR LCLWDLEEGR NTIMDSVQLD SVGFCRGSIL
VRGQQCWMLA VPGKGSDEVQ ILEMPSKTSV CTLKPEADAR PGMPMCLGLW QTNSSLRPLL
LAGYEDGSVT LWDISERKVC SQITCHEEPV MGLDFDSQKA KGISGSAGKV LAVWSLDDQQ
SLQVKKTHEL TNPGIAEVTI RPDHKILATA GWDHRIRVFH WRTMKPLAVL AFHSAPVYCV
AFAADGLLAA GSKDQRISIW SLYPCP
