ID   AMN1_YARLI              Reviewed;         717 AA.
AC   Q6C725;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Antagonist of mitotic exit network protein 1;
GN   Name=AMN1; OrderedLocusNames=YALI0E04356g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Negative regulator of the mitotic exit network (MEN),
CC       required for multiple cell cycle checkpoints. Required for daughter
CC       cell separation and chromosome stability. Involved in copper
CC       sensitivity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P38285}. Nucleus
CC       {ECO:0000250|UniProtKB:P38285}.
CC   -!- SIMILARITY: Belongs to the AMN1 family. {ECO:0000305}.
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DR   EMBL; CR382131; CAG79118.1; -; Genomic_DNA.
DR   RefSeq; XP_503537.1; XM_503537.1.
DR   AlphaFoldDB; Q6C725; -.
DR   SMR; Q6C725; -.
DR   STRING; 4952.CAG79118; -.
DR   EnsemblFungi; CAG79118; CAG79118; YALI0_E04356g.
DR   GeneID; 2912194; -.
DR   KEGG; yli:YALI0E04356g; -.
DR   VEuPathDB; FungiDB:YALI0_E04356g; -.
DR   HOGENOM; CLU_385528_0_0_1; -.
DR   InParanoid; Q6C725; -.
DR   Proteomes; UP000001300; Chromosome E.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   SMART; SM00367; LRR_CC; 5.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..717
FT                   /note="Antagonist of mitotic exit network protein 1"
FT                   /id="PRO_0000277847"
FT   REGION          1..149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          697..717
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..73
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        130..149
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   717 AA;  80594 MW;  CBE9B514542323EC CRC64;
     MQPSTPKRSK GDWSTTQQRR SYSTPSALIF GSPEDTPASS SSFASSSSTG TTPNTSPQRP
     SQLPKSPSSP TPSRRGLRGK LASLTLGAAE RVRSISGRID DREPPVYAPP AQPLANPQES
     LMGWMVERNN GGTRPQQRHP PPRLDTSNYG VSAISNNGLL TPEQTPESSP IQPIHRAKGR
     TTSYYQTQPF KYTSSLREDP FIDRNRNRIK EVQELDFEEF NNSEDDFCLS ETDVHSEFSS
     SADSTSSQCH KALRIPEILY NILSHVEADV QVPHEPPPQR RRPLSLRHAF LIYGDREKAH
     QAWERALKEE QTPTQQMFKG DGALHGCLLV NKFWFEVSRK LLYNKLHFCD SQKWRQFVHM
     SSDTGSPEDL ITWSRSSHHR SLSRSTGQPN LHQLANGEAE MNDYFDTPTK LFVLHKISNA
     QQSEIDLLQH KIGGALEWLE FYTCAAIVPP LGLLAGGSLQ KIVLPGCTKV DDAFLKLVAE
     NCPRLQIADL RACEKVSNEG LVALAGKCPQ LKLLNVGRTQ MGHLISYRGI SAIARKTQVN
     TLGAAGCFVC DKSMWELAWY RGHSLDRLSL NGCTLLTNDS IPRILPYTSN LAVLELRGCT
     QITDFKSIIK FKRYQERHKR EPLIEGCEIF ESRMREAEFQ LEMDISREIL RDCVQWIYAP
     DHDQESVRVK RKKVVPNFAS TSRLSFIPHG SDAARKLAAT STRVESSSRH HSSRPSH