ID   AMN1_MOUSE              Reviewed;         258 AA.
AC   B8JKV0;
DT   07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Protein AMN1 homolog;
GN   Name=Amn1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3]
RP   INTERACTION WITH TASOR, AND TISSUE SPECIFICITY.
RX   PubMed=31112734; DOI=10.1016/j.yexcr.2019.05.018;
RA   Gresakova V., Novosadova V., Prochazkova M., Bhargava S., Jenickova I.,
RA   Prochazka J., Sedlacek R.;
RT   "Fam208a orchestrates interaction protein network essential for early
RT   embryonic development and cell division.";
RL   Exp. Cell Res. 382:111437-111437(2019).
CC   -!- SUBUNIT: Interacts with TASOR. {ECO:0000269|PubMed:31112734}.
CC   -!- TISSUE SPECIFICITY: Expressed in the Sertoli cells of the testis.
CC       {ECO:0000269|PubMed:31112734}.
CC   -!- SIMILARITY: Belongs to the AMN1 family. {ECO:0000305}.
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DR   EMBL; AC128664; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC132412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS51961.1; -.
DR   RefSeq; NP_001106895.1; NM_001113424.1.
DR   AlphaFoldDB; B8JKV0; -.
DR   SMR; B8JKV0; -.
DR   STRING; 10090.ENSMUSP00000107160; -.
DR   iPTMnet; B8JKV0; -.
DR   PhosphoSitePlus; B8JKV0; -.
DR   MaxQB; B8JKV0; -.
DR   PaxDb; B8JKV0; -.
DR   PRIDE; B8JKV0; -.
DR   ProteomicsDB; 320382; -.
DR   Antibodypedia; 24696; 144 antibodies from 24 providers.
DR   Ensembl; ENSMUST00000111535; ENSMUSP00000107160; ENSMUSG00000068250.
DR   GeneID; 232566; -.
DR   KEGG; mmu:232566; -.
DR   UCSC; uc012evz.1; mouse.
DR   CTD; 196394; -.
DR   MGI; MGI:2442933; Amn1.
DR   VEuPathDB; HostDB:ENSMUSG00000068250; -.
DR   eggNOG; KOG1947; Eukaryota.
DR   GeneTree; ENSGT00730000111305; -.
DR   InParanoid; B8JKV0; -.
DR   OMA; EVHMDHC; -.
DR   OrthoDB; 1046098at2759; -.
DR   PhylomeDB; B8JKV0; -.
DR   TreeFam; TF331575; -.
DR   BioGRID-ORCS; 232566; 5 hits in 71 CRISPR screens.
DR   ChiTaRS; Amn1; mouse.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; B8JKV0; protein.
DR   Bgee; ENSMUSG00000068250; Expressed in spermatocyte and 225 other tissues.
DR   ExpressionAtlas; B8JKV0; baseline and differential.
DR   Genevisible; B8JKV0; MM.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13516; LRR_6; 3.
DR   SMART; SM00367; LRR_CC; 6.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..258
FT                   /note="Protein AMN1 homolog"
FT                   /id="PRO_0000451143"
SQ   SEQUENCE   258 AA;  28466 MW;  B94B1C979B396B97 CRC64;
     MPLSGVVSQL LELCLQYLVI NISRYISDIK YLPSNIKDRL IKIMSIRGRI TDSNISEVLH
     PEVQRLDLRS CDISDVALQH LCKCRKLKAL NLKSCREHRN SITSEGIKAV ASSCSDLHEI
     YLKGCCSVTD EGVLALALNC HLLKIIDLGG CLGITDVSLH ALGKNCPFLQ CVDISTTQVS
     DNGVVALVSG PCAKQLEEIN MRYCINLTDK AVEAALTACP RICILLFHGC PLITDRSQEV
     LEQLIGSRKL KQVTWSVY