ID   AMN1_DEBHA              Reviewed;         536 AA.
AC   Q6BIN3;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Antagonist of mitotic exit network protein 1;
GN   Name=AMN1; OrderedLocusNames=DEHA2G08998g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Negative regulator of the mitotic exit network (MEN),
CC       required for multiple cell cycle checkpoints. Required for daughter
CC       cell separation and chromosome stability. Involved in copper
CC       sensitivity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P38285}. Nucleus
CC       {ECO:0000250|UniProtKB:P38285}.
CC   -!- SIMILARITY: Belongs to the AMN1 family. {ECO:0000305}.
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DR   EMBL; CR382139; CAG90406.2; -; Genomic_DNA.
DR   RefSeq; XP_461938.2; XM_461938.1.
DR   AlphaFoldDB; Q6BIN3; -.
DR   SMR; Q6BIN3; -.
DR   STRING; 4959.XP_461938.2; -.
DR   EnsemblFungi; CAG90406; CAG90406; DEHA2G08998g.
DR   GeneID; 2904827; -.
DR   KEGG; dha:DEHA2G08998g; -.
DR   eggNOG; KOG1947; Eukaryota.
DR   HOGENOM; CLU_031725_0_0_1; -.
DR   InParanoid; Q6BIN3; -.
DR   OMA; NCLLVNK; -.
DR   OrthoDB; 1027299at2759; -.
DR   Proteomes; UP000000599; Chromosome G.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13516; LRR_6; 2.
DR   SMART; SM00367; LRR_CC; 4.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..536
FT                   /note="Antagonist of mitotic exit network protein 1"
FT                   /id="PRO_0000277844"
FT   REGION          27..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          94..123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   536 AA;  61556 MW;  4C487AE888D92E5C CRC64;
     MNITPVSKNT TEPLACIENI DNHIYDYSPS NEEPKYLKRS KSESTTKLSR QLPRTPSNKY
     HARNKRRPYS TTPPISLNIP SSPFIHSEFS LNSSSSESSD LESLPDLSED RDTPFSSPIN
     RNPLTPNNSF FSFTKKNGPI ECLLPKRTQI SIFEIPEIVY KIVEFADIQN TAVPQEGTPI
     RRKPLSSNHA LLIYGDKKQA ELSLQDHYDE HNNDGMLFNC LQVNKLFNQV TTEIISQKFF
     FSDEMKLHSF LQNLKITQIK SKPSLFVFHK LFHAKQDIIE LIKSHMDFSN LQWLEFYMCP
     KLLPTPEFLS CGTKIKKIVI TGSKVIDDGF LSMVAKKCPN LEVLDIRACE LISDSGIYQI
     AKRCTKLTTV NFGRKNKGNL ITDSSICILI RNNPNLKTVG LAGCHITDKT LWDLAIRCSD
     HLQRLSLNNC PHITNQSIPL ILHSNLFKNI SVLELRFANQ ITNFKPIIEF KRRQEFRGIS
     ILIEVCESLC LMMREQELEM DKVISQRIFE DISYWANDNN DGDVPYQSFI NSRRHK