AMGO3_HUMAN
ID AMGO3_HUMAN Reviewed; 504 AA.
AC Q86WK7; Q494V6; Q96JH6;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Amphoterin-induced protein 3;
DE AltName: Full=AMIGO-3;
DE AltName: Full=Alivin-3;
DE Flags: Precursor;
GN Name=AMIGO3 {ECO:0000312|EMBL:AAO48944.1};
GN Synonyms=ALI3 {ECO:0000250|UniProtKB:Q8C2S7},
GN KIAA1851 {ECO:0000312|EMBL:BAB47480.1}; ORFNames=UNQ6084/PRO20089;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000312|EMBL:AAO48944.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryonic kidney {ECO:0000269|PubMed:12629050};
RX PubMed=12629050; DOI=10.1083/jcb.200209074;
RA Kuja-Panula J., Kiiltomaeki M., Yamashiro T., Rouhiainen A., Rauvala H.;
RT "AMIGO, a transmembrane protein implicated in axon tract development,
RT defines a novel protein family with leucine-rich repeats.";
RL J. Cell Biol. 160:963-973(2003).
RN [2] {ECO:0000312|EMBL:BAB47480.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000312|EMBL:BAB47480.1};
RX PubMed=11347906; DOI=10.1093/dnares/8.2.85;
RA Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 8:85-95(2001).
RN [3] {ECO:0000312|EMBL:AAQ88501.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May mediate heterophilic cell-cell interaction. May
CC contribute to signal transduction through its intracellular domain (By
CC similarity). {ECO:0000250|UniProtKB:Q80ZD5}.
CC -!- SUBUNIT: Binds AMIGO1 or AMIGO2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. AMIGO family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB47480.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY237003; AAO48944.1; -; mRNA.
DR EMBL; AB058754; BAB47480.1; ALT_INIT; mRNA.
DR EMBL; AY358134; AAQ88501.1; -; mRNA.
DR EMBL; BC101363; AAI01364.1; -; mRNA.
DR EMBL; BC101364; AAI01365.1; -; mRNA.
DR CCDS; CCDS33759.1; -.
DR RefSeq; NP_942015.1; NM_198722.2.
DR AlphaFoldDB; Q86WK7; -.
DR SMR; Q86WK7; -.
DR BioGRID; 132150; 37.
DR IntAct; Q86WK7; 12.
DR STRING; 9606.ENSP00000323096; -.
DR GlyGen; Q86WK7; 5 sites.
DR iPTMnet; Q86WK7; -.
DR PhosphoSitePlus; Q86WK7; -.
DR BioMuta; AMIGO3; -.
DR DMDM; 68052343; -.
DR MassIVE; Q86WK7; -.
DR PaxDb; Q86WK7; -.
DR PeptideAtlas; Q86WK7; -.
DR PRIDE; Q86WK7; -.
DR ProteomicsDB; 70179; -.
DR Antibodypedia; 13729; 140 antibodies from 23 providers.
DR DNASU; 386724; -.
DR Ensembl; ENST00000320431.8; ENSP00000323096.7; ENSG00000176020.9.
DR GeneID; 386724; -.
DR KEGG; hsa:386724; -.
DR MANE-Select; ENST00000320431.8; ENSP00000323096.7; NM_198722.3; NP_942015.1.
DR UCSC; uc003cxj.4; human.
DR CTD; 386724; -.
DR DisGeNET; 386724; -.
DR GeneCards; AMIGO3; -.
DR HGNC; HGNC:24075; AMIGO3.
DR HPA; ENSG00000176020; Low tissue specificity.
DR MIM; 615691; gene.
DR neXtProt; NX_Q86WK7; -.
DR PharmGKB; PA142672627; -.
DR VEuPathDB; HostDB:ENSG00000176020; -.
DR eggNOG; ENOG502QUWU; Eukaryota.
DR GeneTree; ENSGT00950000183146; -.
DR HOGENOM; CLU_030478_0_0_1; -.
DR InParanoid; Q86WK7; -.
DR OMA; PQECSAQ; -.
DR OrthoDB; 564038at2759; -.
DR PhylomeDB; Q86WK7; -.
DR TreeFam; TF326838; -.
DR PathwayCommons; Q86WK7; -.
DR SignaLink; Q86WK7; -.
DR BioGRID-ORCS; 386724; 13 hits in 1022 CRISPR screens.
DR GenomeRNAi; 386724; -.
DR Pharos; Q86WK7; Tdark.
DR PRO; PR:Q86WK7; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q86WK7; protein.
DR Bgee; ENSG00000176020; Expressed in hindlimb stylopod muscle and 89 other tissues.
DR Genevisible; Q86WK7; HS.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IBA:GO_Central.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; ISS:UniProtKB.
DR GO; GO:0010977; P:negative regulation of neuron projection development; IEA:Ensembl.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR031283; AMIGO.
DR InterPro; IPR031285; AMIGO3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24368; PTHR24368; 1.
DR PANTHER; PTHR24368:SF62; PTHR24368:SF62; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 6.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 5.
PE 2: Evidence at transcript level;
KW Cell adhesion; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Leucine-rich repeat; Membrane; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..504
FT /note="Amphoterin-induced protein 3"
FT /evidence="ECO:0000255"
FT /id="PRO_0000014513"
FT TOPO_DOM 20..383
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 405..504
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 25..61
FT /note="LRRNT"
FT REPEAT 62..83
FT /note="LRR 1"
FT REPEAT 86..107
FT /note="LRR 2"
FT REPEAT 110..133
FT /note="LRR 3"
FT REPEAT 134..155
FT /note="LRR 4"
FT REPEAT 158..178
FT /note="LRR 5"
FT REPEAT 184..207
FT /note="LRR 6"
FT DOMAIN 219..275
FT /note="LRRCT"
FT DOMAIN 277..370
FT /note="Ig-like C2-type"
FT /evidence="ECO:0000255"
FT REGION 422..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 107
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 272
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 301
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 362
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 368
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 34..40
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 38..47
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 223..251
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 225..273
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 300..352
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 504 AA; 55250 MW; 92044CA180BD34FA CRC64;
MTWLVLLGTL LCMLRVGLGT PDSEGFPPRA LHNCPYKCIC AADLLSCTGL GLQDVPAELP
AATADLDLSH NALQRLRPGW LAPLFQLRAL HLDHNELDAL GRGVFVNASG LRLLDLSSNT
LRALGRHDLD GLGALEKLLL FNNRLVHLDE HAFHGLRALS HLYLGCNELA SFSFDHLHGL
SATHLLTLDL SSNRLGHISV PELAALPAFL KNGLYLHNNP LPCDCRLYHL LQRWHQRGLS
AVRDFAREYV CLAFKVPASR VRFFQHSRVF ENCSSAPALG LERPEEHLYA LVGRSLRLYC
NTSVPAMRIA WVSPQQELLR APGSRDGSIA VLADGSLAIG NVQEQHAGLF VCLATGPRLH
HNQTHEYNVS VHFPRPEPEA FNTGFTTLLG CAVGLVLVLL YLFAPPCRCC RRACRCRRWP
QTPSPLQELS AQSSVLSTTP PDAPSRKASV HKHVVFLEPG RRGLNGRVQL AVAEEFDLYN
PGGLQLKAGS ESASSIGSEG PMTT
