ID   GLPA_PIG                Reviewed;         133 AA.
AC   P02725;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Glycophorin-A;
DE   AltName: CD_antigen=CD235a;
GN   Name=GYPA;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   PROTEIN SEQUENCE OF 1-43 AND 47-106.
RX   PubMed=7462200; DOI=10.1093/oxfordjournals.jbchem.a133143;
RA   Honma K., Tomita M., Hamada A.;
RT   "Amino acid sequence and attachment sites of oligosaccharide units of
RT   porcine erythrocyte glycophorin.";
RL   J. Biochem. 88:1679-1691(1980).
RN   [2]
RP   PROTEIN SEQUENCE OF 36-54 AND 98-133.
RX   PubMed=546438; DOI=10.1016/0005-2795(79)90211-3;
RA   Honma K., Tomita M., Hamada A.;
RT   "Partial amino acid sequence of glycophorin from porcine erythrocyte
RT   membranes.";
RL   Biochim. Biophys. Acta 580:210-215(1979).
CC   -!- FUNCTION: Glycophorin A is the major intrinsic membrane
CC       sialoglycoprotein of the erythrocyte. Appears to be important for the
CC       function of SLC4A1 and is required for high activity of SLC4A1. May be
CC       involved in translocation of SLC4A1 to the plasma membrane (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC   -!- SIMILARITY: Belongs to the glycophorin-A family. {ECO:0000305}.
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DR   PIR; A91958; GFPGE.
DR   AlphaFoldDB; P02725; -.
DR   SMR; P02725; -.
DR   iPTMnet; P02725; -.
DR   PRIDE; P02725; -.
DR   InParanoid; P02725; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   InterPro; IPR001195; Glycophorin.
DR   InterPro; IPR018938; Glycophorin_CS.
DR   PANTHER; PTHR13813; PTHR13813; 1.
DR   PIRSF; PIRSF002466; Glycophorin; 1.
DR   PROSITE; PS00312; GLYCOPHORIN_A; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Membrane; Reference proteome;
KW   Sialic acid; Transmembrane; Transmembrane helix.
FT   CHAIN           1..133
FT                   /note="Glycophorin-A"
FT                   /id="PRO_0000149049"
FT   TOPO_DOM        1..62
FT                   /note="Extracellular"
FT   TRANSMEM        63..85
FT                   /note="Helical"
FT   TOPO_DOM        86..133
FT                   /note="Cytoplasmic"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          93..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        1
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000269|PubMed:7462200"
FT   CARBOHYD        6
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000269|PubMed:7462200"
FT   CARBOHYD        11
FT                   /note="O-linked (GalNAc...) serine"
FT                   /evidence="ECO:0000269|PubMed:7462200"
FT   CARBOHYD        13
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000269|PubMed:7462200"
FT   CARBOHYD        19
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:7462200"
FT   CARBOHYD        21
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000269|PubMed:7462200"
FT   CARBOHYD        23
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000269|PubMed:7462200"
FT   CARBOHYD        30
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000269|PubMed:7462200"
FT   CARBOHYD        31
FT                   /note="O-linked (GalNAc...) serine"
FT                   /evidence="ECO:0000269|PubMed:7462200"
FT   CARBOHYD        39
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:7462200"
FT   CARBOHYD        41
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000269|PubMed:7462200"
FT   CARBOHYD        48
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000269|PubMed:7462200"
SQ   SEQUENCE   133 AA;  14000 MW;  7B936EF93652547F CRC64;
     TETPVTGEQG SATPGNVSNA TVTAGKPSAT SPGVMTIKNT TAVVQKETGV PESYHQDFSH
     AEITGIIFAV MAGLLLIIFL IAYLIRRMIK KPLPVPKPQD SPDIGTENTA DPSELQDTED
     PPLTSVEIET PAS