GLPA_MACFU
ID GLPA_MACFU Reviewed; 144 AA.
AC P14221;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Glycophorin-A;
DE AltName: Full=Glycophorin-MK;
DE AltName: CD_antigen=CD235a;
GN Name=GYPA;
OS Macaca fuscata fuscata (Japanese macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9543;
RN [1]
RP PROTEIN SEQUENCE.
RX PubMed=2605264; DOI=10.1016/0167-4838(89)90009-5;
RA Murayama J., Utsumi H., Hamada A.;
RT "Amino acid sequence of monkey erythrocyte glycophorin MK. Its amino acid
RT sequence has a striking homology with that of human glycophorin A.";
RL Biochim. Biophys. Acta 999:273-280(1989).
CC -!- FUNCTION: Glycophorin A is the major intrinsic membrane
CC sialoglycoprotein of the erythrocyte. Appears to be important for the
CC function of SLC4A1 and is required for high activity of SLC4A1. May be
CC involved in translocation of SLC4A1 to the plasma membrane (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- SIMILARITY: Belongs to the glycophorin-A family. {ECO:0000305}.
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DR AlphaFoldDB; P14221; -.
DR SMR; P14221; -.
DR GlyConnect; 190; 1 O-Linked glycan.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR001195; Glycophorin.
DR InterPro; IPR018938; Glycophorin_CS.
DR PANTHER; PTHR13813; PTHR13813; 1.
DR PIRSF; PIRSF002466; Glycophorin; 1.
DR PROSITE; PS00312; GLYCOPHORIN_A; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Glycoprotein; Membrane; Phosphoprotein;
KW Sialic acid; Transmembrane; Transmembrane helix.
FT CHAIN 1..144
FT /note="Glycophorin-A"
FT /id="PRO_0000149047"
FT TRANSMEM 70..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 118
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P02724"
FT CARBOHYD 2
FT /note="O-linked (GalNAc...) serine"
FT CARBOHYD 3
FT /note="O-linked (GalNAc...) threonine"
FT CARBOHYD 4
FT /note="O-linked (GalNAc...) threonine"
FT CARBOHYD 8
FT /note="O-linked (GalNAc...) threonine"
FT CARBOHYD 10
FT /note="O-linked (GalNAc...) threonine"
FT CARBOHYD 11
FT /note="O-linked (GalNAc...) serine"
FT CARBOHYD 12
FT /note="O-linked (GalNAc...) serine"
FT CARBOHYD 13
FT /note="O-linked (GalNAc...) serine"
FT CARBOHYD 14
FT /note="O-linked (GalNAc...) serine"
FT CARBOHYD 22
FT /note="O-linked (GalNAc...) serine"
FT CARBOHYD 23
FT /note="O-linked (GalNAc...) serine"
FT CARBOHYD 30
FT /note="O-linked (GalNAc...) threonine"
FT CARBOHYD 36
FT /note="O-linked (GalNAc...) threonine"
FT CARBOHYD 38
FT /note="O-linked (GalNAc...) threonine"
FT CARBOHYD 44
FT /note="O-linked (GalNAc...) threonine"
FT CARBOHYD 45
FT /note="O-linked (GalNAc...) threonine"
FT CARBOHYD 48
FT /note="O-linked (GalNAc...) serine"
FT CARBOHYD 51
FT /note="O-linked (GalNAc...) threonine"
FT VARIANT 28
FT /note="K -> R"
SQ SEQUENCE 144 AA; 15779 MW; 052867880A7A7147 CRC64;
SSTTVPATHT SSSSLGPEQY VSSQSNDKHT SDSHPTPTSA HEVTTEFSGR THYPPEEDDR
VQLVHEFSEL VIALIIFGVM AGVIGTILFI SYGSRRLIKK SESDVQPLPP PDAEVPLSSV
EIEDPEETDE LNSFTKPNQE RNES
