GLL3_CHICK
ID GLL3_CHICK Reviewed; 80 AA.
AC Q9DG58; Q0PWH2; Q6GXJ2;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Gallinacin-3;
DE Short=Gal-3;
DE AltName: Full=Beta-defensin 3;
DE Flags: Precursor;
GN Name=GAL3;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Trachea;
RX PubMed=11254635; DOI=10.1128/iai.69.4.2684-2691.2001;
RA Zhao C., Nguyen T., Liu L., Sacco R.E., Brogden K.A., Lehrer R.I.;
RT "Gallinacin-3, an inducible epithelial beta-defensin in the chicken.";
RL Infect. Immun. 69:2684-2691(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15310403; DOI=10.1186/1471-2164-5-56;
RA Xiao Y., Hughes A.L., Ando J., Matsuda Y., Cheng J.-F., Skinner-Noble D.,
RA Zhang G.;
RT "A genome-wide screen identifies a single beta-defensin gene cluster in the
RT chicken: implications for the origin and evolution of mammalian
RT defensins.";
RL BMC Genomics 5:56-56(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Zhang H., Bi Y., Cao Y., Chen X.;
RT "Chicken defensin gene structure.";
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 9-80.
RC STRAIN=Guangxi Huang, Huiyang bearded, Qingyuan Ma, Taihe silkies, and
RC Xinghua;
RA Chen Y., Cao Y., Xie Q., Bi Y., Chen J.;
RT "Chicken beta-defensin in China chicken breeds.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=15148642; DOI=10.1007/s00251-004-0675-0;
RA Lynn D.J., Higgs R., Gaines S., Tierney J., James T., Lloyd A.T.,
RA Fares M.A., Mulcahy G., O'Farrelly C.;
RT "Bioinformatic discovery and initial characterisation of nine novel
RT antimicrobial peptide genes in the chicken.";
RL Immunogenetics 56:170-177(2004).
RN [6]
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=16394622; DOI=10.1262/jrd.17070;
RA Yoshimura Y., Ohashi H., Subedi K., Nishibori M., Isobe N.;
RT "Effects of age, egg-laying activity, and Salmonella-inoculation on the
RT expressions of gallinacin mRNA in the vagina of the hen oviduct.";
RL J. Reprod. Dev. 52:211-218(2006).
RN [7]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=17244739; DOI=10.1530/rep-06-0083;
RA Subedi K., Isobe N., Nishibori M., Yoshimura Y.;
RT "Changes in the expression of gallinacins, antimicrobial peptides, in
RT ovarian follicles during follicular growth and in response to
RT lipopolysaccharide in laying hens (Gallus domesticus).";
RL Reproduction 133:127-133(2007).
CC -!- FUNCTION: Has bactericidal activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted. Cytoplasmic granule.
CC -!- TISSUE SPECIFICITY: Strongly expressed in the tongue, bone marrow,
CC bursa of Fabricius and trachea. Also expressed in skin, esophagus and
CC air sacs. Weak expression in the large intestine, kidney and ovary.
CC Expressed in the vagina and ovarian stroma, but not in the ovarian
CC follicle. {ECO:0000269|PubMed:11254635, ECO:0000269|PubMed:15148642,
CC ECO:0000269|PubMed:16394622, ECO:0000269|PubMed:17244739}.
CC -!- DEVELOPMENTAL STAGE: In the vagina expression is higher in laying hens
CC than in non-laying hens, and is higher in older laying hens than in
CC young laying hens. {ECO:0000269|PubMed:17244739}.
CC -!- INDUCTION: Expression in cultured vaginal cells is increased by LPS and
CC S.enteritidis. {ECO:0000269|PubMed:16394622}.
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AF181952; AAG09212.1; -; mRNA.
DR EMBL; AY621318; AAT48927.1; -; Genomic_DNA.
DR EMBL; AY677340; AAT77774.1; -; Genomic_DNA.
DR EMBL; DQ677634; ABG73368.1; -; mRNA.
DR EMBL; DQ858300; ABI48216.1; -; mRNA.
DR EMBL; DQ858313; ABI48229.1; -; mRNA.
DR EMBL; DQ858326; ABI48242.1; -; mRNA.
DR EMBL; DQ858340; ABI48256.1; -; mRNA.
DR RefSeq; NP_989981.1; NM_204650.2.
DR AlphaFoldDB; Q9DG58; -.
DR SMR; Q9DG58; -.
DR STRING; 9031.ENSGALP00000026851; -.
DR PaxDb; Q9DG58; -.
DR GeneID; 395363; -.
DR KEGG; gga:395363; -.
DR CTD; 395363; -.
DR VEuPathDB; HostDB:geneid_395363; -.
DR HOGENOM; CLU_2589016_0_0_1; -.
DR InParanoid; Q9DG58; -.
DR OrthoDB; 1635342at2759; -.
DR PRO; PR:Q9DG58; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR InterPro; IPR001855; Defensin_beta-typ.
DR Pfam; PF00711; Defensin_beta; 1.
PE 2: Evidence at transcript level;
KW Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PROPEP 21..22
FT /evidence="ECO:0000255"
FT /id="PRO_0000007014"
FT CHAIN 23..80
FT /note="Gallinacin-3"
FT /id="PRO_0000007015"
FT DISULFID 25..53
FT /evidence="ECO:0000250"
FT DISULFID 32..47
FT /evidence="ECO:0000250"
FT DISULFID 37..54
FT /evidence="ECO:0000250"
FT CONFLICT 2..4
FT /note="RIV -> KIL (in Ref. 2; AAT48927)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 80 AA; 8746 MW; 496BBC6BFB3F5C3F CRC64;
MRIVYLLIPF FLLFLQGAAG TATQCRIRGG FCRVGSCRFP HIAIGKCATF ISCCGRAYEV
DALNSVRTSP WLLAPGNNPH
