GIPC2_HUMAN
ID GIPC2_HUMAN Reviewed; 315 AA.
AC Q8TF65; Q8IYD3; Q9NXS7;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=PDZ domain-containing protein GIPC2;
GN Name=GIPC2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=11836570;
RA Kirikoshi H., Katoh M.;
RT "Molecular cloning and characterization of human GIPC2, a novel gene
RT homologous to human GIPC1 and Xenopus Kermit.";
RL Int. J. Oncol. 20:571-576(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PRO-206.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 85-315.
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [6]
RP X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 112-200.
RG Structural genomics consortium (SGC);
RT "Crystal structure of the PDZ domain of PDZ domain-containing protein
RT GIPC2.";
RL Submitted (MAR-2009) to the PDB data bank.
CC -!- SUBUNIT: Probably interacts with SEMA5A. {ECO:0000250}.
CC -!- INTERACTION:
CC Q8TF65; Q99895: CTRC; NbExp=3; IntAct=EBI-712067, EBI-10295404;
CC Q8TF65; Q8TF65: GIPC2; NbExp=7; IntAct=EBI-712067, EBI-712067;
CC Q8TF65; A5PKX9: INADL; NbExp=3; IntAct=EBI-712067, EBI-12035052;
CC Q8TF65; Q15306: IRF4; NbExp=5; IntAct=EBI-712067, EBI-751345;
CC Q8TF65; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-712067, EBI-741037;
CC Q8TF65; Q9HB19: PLEKHA2; NbExp=8; IntAct=EBI-712067, EBI-4401947;
CC Q8TF65; P23497: SP100; NbExp=4; IntAct=EBI-712067, EBI-751145;
CC Q8TF65; P23497-2: SP100; NbExp=3; IntAct=EBI-712067, EBI-6589365;
CC Q8TF65; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-712067, EBI-10180829;
CC Q8TF65; Q9HCK0: ZBTB26; NbExp=3; IntAct=EBI-712067, EBI-3918996;
CC Q8TF65; Q8N3Z6: ZCCHC7; NbExp=3; IntAct=EBI-712067, EBI-7265024;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed at highest levels in ascending colon and
CC at moderate levels in adult kidney. Expressed at low levels in adult
CC pancreas and at very low levels in adult liver. Expression is down-
CC regulated in several primary tumors, such as kidney, colon and rectal
CC tumors. {ECO:0000269|PubMed:11836570}.
CC -!- SIMILARITY: Belongs to the GIPC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA90933.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB073737; BAB84711.1; -; mRNA.
DR EMBL; BC036075; AAH36075.1; -; mRNA.
DR EMBL; AK000082; BAA90933.1; ALT_INIT; mRNA.
DR CCDS; CCDS685.1; -.
DR RefSeq; NP_001291654.1; NM_001304725.1.
DR RefSeq; NP_060125.4; NM_017655.5.
DR PDB; 3GGE; X-ray; 2.60 A; A/B/C=112-200.
DR PDBsum; 3GGE; -.
DR AlphaFoldDB; Q8TF65; -.
DR SMR; Q8TF65; -.
DR BioGRID; 120167; 26.
DR IntAct; Q8TF65; 25.
DR STRING; 9606.ENSP00000359795; -.
DR iPTMnet; Q8TF65; -.
DR PhosphoSitePlus; Q8TF65; -.
DR BioMuta; GIPC2; -.
DR DMDM; 74716120; -.
DR EPD; Q8TF65; -.
DR jPOST; Q8TF65; -.
DR MassIVE; Q8TF65; -.
DR MaxQB; Q8TF65; -.
DR PaxDb; Q8TF65; -.
DR PeptideAtlas; Q8TF65; -.
DR PRIDE; Q8TF65; -.
DR ProteomicsDB; 74565; -.
DR Antibodypedia; 19742; 247 antibodies from 29 providers.
DR DNASU; 54810; -.
DR Ensembl; ENST00000370759.4; ENSP00000359795.3; ENSG00000137960.6.
DR GeneID; 54810; -.
DR KEGG; hsa:54810; -.
DR MANE-Select; ENST00000370759.4; ENSP00000359795.3; NM_017655.6; NP_060125.4.
DR UCSC; uc001dik.4; human.
DR CTD; 54810; -.
DR DisGeNET; 54810; -.
DR GeneCards; GIPC2; -.
DR HGNC; HGNC:18177; GIPC2.
DR HPA; ENSG00000137960; Tissue enhanced (intestine, kidney, lymphoid tissue).
DR MIM; 619089; gene.
DR neXtProt; NX_Q8TF65; -.
DR OpenTargets; ENSG00000137960; -.
DR PharmGKB; PA142671735; -.
DR VEuPathDB; HostDB:ENSG00000137960; -.
DR eggNOG; KOG3938; Eukaryota.
DR GeneTree; ENSGT00390000003420; -.
DR HOGENOM; CLU_044527_1_0_1; -.
DR InParanoid; Q8TF65; -.
DR OMA; NGVGCAF; -.
DR OrthoDB; 1442796at2759; -.
DR PhylomeDB; Q8TF65; -.
DR TreeFam; TF313878; -.
DR PathwayCommons; Q8TF65; -.
DR SignaLink; Q8TF65; -.
DR BioGRID-ORCS; 54810; 18 hits in 1064 CRISPR screens.
DR ChiTaRS; GIPC2; human.
DR EvolutionaryTrace; Q8TF65; -.
DR GeneWiki; GIPC2; -.
DR GenomeRNAi; 54810; -.
DR Pharos; Q8TF65; Tbio.
DR PRO; PR:Q8TF65; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8TF65; protein.
DR Bgee; ENSG00000137960; Expressed in jejunal mucosa and 134 other tissues.
DR ExpressionAtlas; Q8TF65; baseline and differential.
DR Genevisible; Q8TF65; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR017379; GIPC1/2/3.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR12259; PTHR12259; 1.
DR Pfam; PF00595; PDZ; 1.
DR PIRSF; PIRSF038083; UCP038083_GIPC; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Reference proteome.
FT CHAIN 1..315
FT /note="PDZ domain-containing protein GIPC2"
FT /id="PRO_0000247188"
FT DOMAIN 117..197
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 61
FT /note="S -> F (in dbSNP:rs17101180)"
FT /id="VAR_027084"
FT VARIANT 206
FT /note="L -> P (in dbSNP:rs540742)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_027085"
FT STRAND 113..121
FT /evidence="ECO:0007829|PDB:3GGE"
FT STRAND 129..132
FT /evidence="ECO:0007829|PDB:3GGE"
FT STRAND 134..137
FT /evidence="ECO:0007829|PDB:3GGE"
FT STRAND 140..144
FT /evidence="ECO:0007829|PDB:3GGE"
FT HELIX 149..152
FT /evidence="ECO:0007829|PDB:3GGE"
FT STRAND 161..165
FT /evidence="ECO:0007829|PDB:3GGE"
FT HELIX 175..184
FT /evidence="ECO:0007829|PDB:3GGE"
FT STRAND 190..198
FT /evidence="ECO:0007829|PDB:3GGE"
SQ SEQUENCE 315 AA; 34354 MW; 244894C6100C679F CRC64;
MPLKLRGKKK AKSKETAGLV EGEPTGAGGG SLSASRAPAR RLVFHAQLAH GSATGRVEGF
SSIQELYAQI AGAFEISPSE ILYCTLNTPK IDMERLLGGQ LGLEDFIFAH VKGIEKEVNV
YKSEDSLGLT ITDNGVGYAF IKRIKDGGVI DSVKTICVGD HIESINGENI VGWRHYDVAK
KLKELKKEEL FTMKLIEPKK AFEIELRSKA GKSSGEKIGC GRATLRLRSK GPATVEEMPS
ETKAKAIEKI DDVLELYMGI RDIDLATTMF EAGKDKVNPD EFAVALDETL GDFAFPDEFV
FDVWGVIGDA KRRGL
