ID   GIL2_ENTHI              Reviewed;         288 AA.
AC   Q03077;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Galactose-inhibitable lectin 35 kDa subunit;
DE   Flags: Precursor;
OS   Entamoeba histolytica.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=5759;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1435873; DOI=10.1016/0166-6851(92)90144-9;
RA   Tannich E., Ebert F., Horstmann R.D.;
RT   "Molecular cloning of cDNA and genomic sequences coding for the 35-
RT   kilodalton subunit of the galactose-inhibitable lectin of pathogenic
RT   Entamoeba histolytica.";
RL   Mol. Biochem. Parasitol. 55:225-227(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 11-288.
RX   PubMed=8226970; DOI=10.1016/s0021-9258(20)80514-6;
RA   McCoy J.J., Mann B.J., Vedvick T.S., Pak Y., Heimark D.B., Petri W.A. Jr.;
RT   "Structural analysis of the light subunit of the Entamoeba histolytica
RT   galactose-specific adherence lectin.";
RL   J. Biol. Chem. 268:24223-24231(1993).
CC   -!- FUNCTION: Lectin that binds galactose.
CC   -!- SUBUNIT: Heterodimer of a heavy (170 kDa) and a light subunit (35 kDa)
CC       linked by disulfide bonds.
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DR   EMBL; M96024; AAA29099.1; -; Genomic_DNA.
DR   EMBL; L06065; AAA16054.1; -; mRNA.
DR   PIR; A48452; A48452.
DR   PIR; A49505; A49505.
DR   AlphaFoldDB; Q03077; -.
DR   VEuPathDB; AmoebaDB:EHI5A_013340; -.
DR   VEuPathDB; AmoebaDB:EHI7A_044310; -.
DR   VEuPathDB; AmoebaDB:EHI8A_227050; -.
DR   VEuPathDB; AmoebaDB:EHI_035690; -.
DR   VEuPathDB; AmoebaDB:KM1_082970; -.
DR   eggNOG; ENOG502RAVA; Eukaryota.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   InterPro; IPR035310; Gal_GalNac_35kDa.
DR   Pfam; PF17337; Gal_GalNac_35kD; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Lectin; Signal.
FT   SIGNAL          1..13
FT   CHAIN           14..288
FT                   /note="Galactose-inhibitable lectin 35 kDa subunit"
FT                   /id="PRO_0000021327"
FT   CONFLICT        11
FT                   /note="S -> A (in Ref. 2; AAA16054)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        64
FT                   /note="E -> K (in Ref. 2; AAA16054)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        167
FT                   /note="E -> G (in Ref. 2; AAA16054)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   288 AA;  33667 MW;  DECF366D3DAFA24B CRC64;
     MIILVLLISY SFGKTQDGKD QLSPNYPYGK MNKDVNFNKP FTSAVDSYQI QQYAENGVFS
     ANQENYVRAK CKTCCRVIFA SDYNYKTNTQ FTDEDDKKGD ERYVMDMEFD DKRSVRFRNG
     GYEQNILLRP LKQGNELQFF EFAPYRMYTS YAIPKRVHDI RGGANEEATL IIWPKNPPLS
     DAPGTRNQRF VYVHPYPTEW YPEYNSTTKY TQNGKTVIKT LKWPTYKRHF YLPYRLDVDL
     CYQARKATDG RSTWTGNKNL NTTSKSYQII ASRCSATEAR QIFIPVFA