GIF3_ARATH
ID GIF3_ARATH Reviewed; 223 AA.
AC Q93VH6; O23091;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=GRF1-interacting factor 3;
DE Short=AtGIF3;
DE AltName: Full=Transcription coactivator GIF3;
GN Name=GIF3; OrderedLocusNames=At4g00850; ORFNames=A_TM018A10_22;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH GRF1, AND TISSUE
RP SPECIFICITY.
RX PubMed=15326298; DOI=10.1073/pnas.0405450101;
RA Kim J.H., Kende H.;
RT "A transcriptional coactivator, AtGIF1, is involved in regulating leaf
RT growth and morphology in Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:13374-13379(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY, AND FUNCTION.
RX PubMed=19648231; DOI=10.1104/pp.109.141838;
RA Lee B.H., Ko J.H., Lee S., Lee Y., Pak J.H., Kim J.H.;
RT "The Arabidopsis GRF-INTERACTING FACTOR gene family performs an overlapping
RT function in determining organ size as well as multiple developmental
RT properties.";
RL Plant Physiol. 151:655-668(2009).
CC -!- FUNCTION: Transcription coactivator that plays a role in the regulation
CC of cell expansion in leaf and cotyledons tissues (By similarity).
CC Component of a network formed by miR396, the GRFs and their interacting
CC factors (GIFs) acting in the regulation of meristem function, at least
CC partially through the control of cell proliferation (By similarity).
CC GIFs are involved in the positive regulation of cell proliferation of
CC lateral organs in a functionally redundant manner. {ECO:0000250,
CC ECO:0000269|PubMed:15326298, ECO:0000269|PubMed:19648231}.
CC -!- SUBUNIT: Interacts with GRF1. {ECO:0000269|PubMed:15326298}.
CC -!- INTERACTION:
CC Q93VH6; O81001: GRF1; NbExp=3; IntAct=EBI-15194507, EBI-1396842;
CC Q93VH6; Q8L8A8: GRF2; NbExp=3; IntAct=EBI-15194507, EBI-1396893;
CC Q93VH6; Q9SJR5: GRF3; NbExp=3; IntAct=EBI-15194507, EBI-3134219;
CC Q93VH6; Q8L8A7: GRF4; NbExp=4; IntAct=EBI-15194507, EBI-1396671;
CC Q93VH6; Q8L8A6: GRF5; NbExp=3; IntAct=EBI-15194507, EBI-1396652;
CC Q93VH6; Q9ZQ12: GRF6; NbExp=3; IntAct=EBI-15194507, EBI-15193797;
CC Q93VH6; Q8S9M3: GRF9; NbExp=3; IntAct=EBI-15194507, EBI-1396638;
CC Q93VH6; Q9LM84: WOX14; NbExp=3; IntAct=EBI-15194507, EBI-15193011;
CC -!- TISSUE SPECIFICITY: Predominantly expressed in shoot tips containing
CC the shoot apical meristem (SAM) and flower buds. Also expressed in
CC mature flowers. {ECO:0000269|PubMed:15326298}.
CC -!- SIMILARITY: Belongs to the SS18 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB62864.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB80894.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY102641; AAM52883.1; -; mRNA.
DR EMBL; AF013294; AAB62864.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161472; CAB80894.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE81945.1; -; Genomic_DNA.
DR EMBL; AF378866; AAK55669.1; -; mRNA.
DR EMBL; AY052732; AAK96446.1; -; mRNA.
DR PIR; T01561; T01561.
DR RefSeq; NP_567194.1; NM_116311.4.
DR AlphaFoldDB; Q93VH6; -.
DR SMR; Q93VH6; -.
DR BioGRID; 13286; 13.
DR IntAct; Q93VH6; 11.
DR STRING; 3702.AT4G00850.1; -.
DR PaxDb; Q93VH6; -.
DR PRIDE; Q93VH6; -.
DR ProteomicsDB; 221891; -.
DR EnsemblPlants; AT4G00850.1; AT4G00850.1; AT4G00850.
DR GeneID; 827995; -.
DR Gramene; AT4G00850.1; AT4G00850.1; AT4G00850.
DR KEGG; ath:AT4G00850; -.
DR Araport; AT4G00850; -.
DR TAIR; locus:2134558; AT4G00850.
DR eggNOG; KOG3227; Eukaryota.
DR HOGENOM; CLU_086253_1_0_1; -.
DR InParanoid; Q93VH6; -.
DR OMA; IINNGMH; -.
DR OrthoDB; 1431258at2759; -.
DR PhylomeDB; Q93VH6; -.
DR PRO; PR:Q93VH6; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q93VH6; baseline and differential.
DR Genevisible; Q93VH6; AT.
DR GO; GO:0005634; C:nucleus; ISS:TAIR.
DR GO; GO:0003713; F:transcription coactivator activity; ISS:TAIR.
DR GO; GO:0051301; P:cell division; IGI:TAIR.
DR GO; GO:0008283; P:cell population proliferation; IBA:GO_Central.
DR GO; GO:0048366; P:leaf development; IMP:TAIR.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR044779; SS18.
DR InterPro; IPR007726; SS18_N.
DR PANTHER; PTHR23107; PTHR23107; 1.
DR Pfam; PF05030; SSXT; 1.
PE 1: Evidence at protein level;
KW Activator; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..223
FT /note="GRF1-interacting factor 3"
FT /id="PRO_0000419320"
FT REGION 179..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 223 AA; 23770 MW; B985EF34A7993CFD CRC64;
MQQSPQMIPM VLPSFPPTNN ITTEQIQKYL DENKKLIMAI LENQNLGKLA ECAQYQALLQ
KNLMYLAAIA DAQPQPPAAT LTSGAMTPQA MAPNPSSMQP PPSYFMQQHQ AVGMAQQIPP
GIFPPRGPLQ FGSPHQFLDP QQQLHQQAMQ GHMGIRPMGL NNNNGLQHQM HHHETALAAN
NAGPNDASGG GKPDGTNMSQ SGADGQGGSA ARHGGGDAKT EGK
