GIF2_ARATH
ID GIF2_ARATH Reviewed; 195 AA.
AC Q9MAL9;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=GRF1-interacting factor 2;
DE Short=AtGIF2;
DE AltName: Full=Transcription coactivator GIF2;
GN Name=GIF2; OrderedLocusNames=At1g01160; ORFNames=F6F3_1, T25K16.15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH GRF1, AND TISSUE
RP SPECIFICITY.
RX PubMed=15326298; DOI=10.1073/pnas.0405450101;
RA Kim J.H., Kende H.;
RT "A transcriptional coactivator, AtGIF1, is involved in regulating leaf
RT growth and morphology in Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:13374-13379(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY, AND FUNCTION.
RX PubMed=19648231; DOI=10.1104/pp.109.141838;
RA Lee B.H., Ko J.H., Lee S., Lee Y., Pak J.H., Kim J.H.;
RT "The Arabidopsis GRF-INTERACTING FACTOR gene family performs an overlapping
RT function in determining organ size as well as multiple developmental
RT properties.";
RL Plant Physiol. 151:655-668(2009).
CC -!- FUNCTION: Transcription coactivator that plays a role in the regulation
CC of cell expansion in leaf and cotyledons tissues (By similarity).
CC Component of a network formed by miR396, the GRFs and their interacting
CC factors (GIFs) acting in the regulation of meristem function, at least
CC partially through the control of cell proliferation (By similarity).
CC GIFs are involved in the positive regulation of cell proliferation of
CC lateral organs in a functionally redundant manner. {ECO:0000250,
CC ECO:0000269|PubMed:15326298, ECO:0000269|PubMed:19648231}.
CC -!- SUBUNIT: Interacts with GRF1. {ECO:0000269|PubMed:15326298}.
CC -!- INTERACTION:
CC Q9MAL9; O81001: GRF1; NbExp=4; IntAct=EBI-1396863, EBI-1396842;
CC Q9MAL9; Q8L8A8: GRF2; NbExp=3; IntAct=EBI-1396863, EBI-1396893;
CC Q9MAL9; Q8L8A7: GRF4; NbExp=3; IntAct=EBI-1396863, EBI-1396671;
CC Q9MAL9; Q8L8A6: GRF5; NbExp=3; IntAct=EBI-1396863, EBI-1396652;
CC Q9MAL9; Q9ZQ12: GRF6; NbExp=3; IntAct=EBI-1396863, EBI-15193797;
CC Q9MAL9; Q8S9M3: GRF9; NbExp=3; IntAct=EBI-1396863, EBI-1396638;
CC Q9MAL9; Q9LM84: WOX14; NbExp=3; IntAct=EBI-1396863, EBI-15193011;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9MAL9-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Predominantly expressed in shoot tips containing
CC the shoot apical meristem (SAM) and flower buds. Also expressed in
CC mature flowers. {ECO:0000269|PubMed:15326298}.
CC -!- SIMILARITY: Belongs to the SS18 family. {ECO:0000305}.
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DR EMBL; AY102640; AAM52882.1; -; mRNA.
DR EMBL; AC007323; AAF26463.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE27247.1; -; Genomic_DNA.
DR EMBL; AF410307; AAK95293.1; -; mRNA.
DR EMBL; AY102133; AAM26700.1; -; mRNA.
DR PIR; H86141; H86141.
DR RefSeq; NP_563619.1; NM_099998.4. [Q9MAL9-1]
DR AlphaFoldDB; Q9MAL9; -.
DR SMR; Q9MAL9; -.
DR BioGRID; 24513; 23.
DR IntAct; Q9MAL9; 23.
DR PRIDE; Q9MAL9; -.
DR ProteomicsDB; 220661; -. [Q9MAL9-1]
DR EnsemblPlants; AT1G01160.1; AT1G01160.1; AT1G01160. [Q9MAL9-1]
DR GeneID; 839278; -.
DR Gramene; AT1G01160.1; AT1G01160.1; AT1G01160. [Q9MAL9-1]
DR KEGG; ath:AT1G01160; -.
DR Araport; AT1G01160; -.
DR HOGENOM; CLU_086253_1_0_1; -.
DR InParanoid; Q9MAL9; -.
DR OMA; GINNGMH; -.
DR PhylomeDB; Q9MAL9; -.
DR PRO; PR:Q9MAL9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9MAL9; baseline and differential.
DR Genevisible; Q9MAL9; AT.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:InterPro.
DR GO; GO:0008283; P:cell population proliferation; IBA:GO_Central.
DR GO; GO:0048366; P:leaf development; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR044779; SS18.
DR InterPro; IPR007726; SS18_N.
DR PANTHER; PTHR23107; PTHR23107; 1.
DR Pfam; PF05030; SSXT; 1.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..195
FT /note="GRF1-interacting factor 2"
FT /id="PRO_0000419319"
FT REGION 166..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 195 AA; 21039 MW; 69A453024E75EE67 CRC64;
MQQQQSPQMF PMVPSIPPAN NITTEQIQKY LDENKKLIMA IMENQNLGKL AECAQYQALL
QKNLMYLAAI ADAQPPPPTP GPSPSTAVAA QMATPHSGMQ PPSYFMQHPQ ASPAGIFAPR
GPLQFGSPLQ FQDPQQQQQI HQQAMQGHMG IRPMGMTNNG MQHAMQQPET GLGGNVGLRG
GKQDGADGQG KDDGK
