GIF1_ARATH
ID GIF1_ARATH Reviewed; 210 AA.
AC Q8L8A5;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=GRF1-interacting factor 1 {ECO:0000303|PubMed:15326298};
DE Short=AtGIF1 {ECO:0000303|PubMed:15326298};
DE AltName: Full=Protein ANGUSTIFOLIA 3 {ECO:0000303|PubMed:15960617};
DE AltName: Full=Transcription coactivator GIF1 {ECO:0000303|PubMed:15326298};
GN Name=GIF1 {ECO:0000303|PubMed:15326298};
GN Synonyms=AN3 {ECO:0000303|PubMed:15960617},
GN GIF {ECO:0000303|PubMed:19648231};
GN OrderedLocusNames=At5g28640 {ECO:0000312|Araport:AT5G28640};
GN ORFNames=F4I4.20 {ECO:0000312|EMBL:AF272705};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DISRUPTION PHENOTYPE, INTERACTION
RP WITH GRF1 AND GRF2, AND TISSUE SPECIFICITY.
RX PubMed=15326298; DOI=10.1073/pnas.0405450101;
RA Kim J.H., Kende H.;
RT "A transcriptional coactivator, AtGIF1, is involved in regulating leaf
RT growth and morphology in Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:13374-13379(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND INTERACTION WITH
RP GRF5 AND GRF9.
RX PubMed=15960617; DOI=10.1111/j.1365-313x.2005.02429.x;
RA Horiguchi G., Kim G.T., Tsukaya H.;
RT "The transcription factor AtGRF5 and the transcription coactivator AN3
RT regulate cell proliferation in leaf primordia of Arabidopsis thaliana.";
RL Plant J. 43:68-78(2005).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=19392710; DOI=10.1111/j.1365-313x.2009.03886.x;
RA Fujikura U., Horiguchi G., Ponce M.R., Micol J.L., Tsukaya H.;
RT "Coordination of cell proliferation and cell expansion mediated by
RT ribosome-related processes in the leaves of Arabidopsis thaliana.";
RL Plant J. 59:499-508(2009).
RN [7]
RP GENE FAMILY, FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=19648231; DOI=10.1104/pp.109.141838;
RA Lee B.H., Ko J.H., Lee S., Lee Y., Pak J.H., Kim J.H.;
RT "The Arabidopsis GRF-INTERACTING FACTOR gene family performs an overlapping
RT function in determining organ size as well as multiple developmental
RT properties.";
RL Plant Physiol. 151:655-668(2009).
RN [8]
RP TISSUE SPECIFICITY.
RX PubMed=21036927; DOI=10.1093/jxb/erq307;
RA Wang L., Gu X., Xu D., Wang W., Wang H., Zeng M., Chang Z., Huang H.,
RA Cui X.;
RT "miR396-targeted AtGRF transcription factors are required for coordination
RT of cell division and differentiation during leaf development in
RT Arabidopsis.";
RL J. Exp. Bot. 62:761-773(2011).
RN [9]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=21097896; DOI=10.1093/pcp/pcq178;
RA Horiguchi G., Nakayama H., Ishikawa N., Kubo M., Demura T., Fukuda H.,
RA Tsukaya H.;
RT "ANGUSTIFOLIA3 plays roles in adaxial/abaxial patterning and growth in leaf
RT morphogenesis.";
RL Plant Cell Physiol. 52:112-124(2011).
RN [10]
RP TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=21880932; DOI=10.1104/pp.111.185066;
RA Ichihashi Y., Kawade K., Usami T., Horiguchi G., Takahashi T., Tsukaya H.;
RT "Key proliferative activity in the junction between the leaf blade and leaf
RT petiole of Arabidopsis.";
RL Plant Physiol. 157:1151-1162(2011).
RN [11]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia, and cv. Wassilewskija;
RX PubMed=22669825; DOI=10.1242/dev.081547;
RA Kanei M., Horiguchi G., Tsukaya H.;
RT "Stable establishment of cotyledon identity during embryogenesis in
RT Arabidopsis by ANGUSTIFOLIA3 and HANABA TARANU.";
RL Development 139:2436-2446(2012).
CC -!- FUNCTION: Transcription coactivator that plays a role in the regulation
CC of cell expansion in leaf and cotyledons tissues. Component of a
CC network formed by miR396, the GRFs and their interacting factors (GIFs)
CC acting in the regulation of meristem function, at least partially
CC through the control of cell proliferation (PubMed:19392710). Appears to
CC function synergistically with GRF1 as a transcriptional coactivator.
CC Acts together with GRF5 for the development of appropriate leaf size
CC and shape through the promotion and/or maintenance of cell
CC proliferation activity in leaf primordia. Plays a role in
CC adaxial/abaxial patterning and growth in leaf morphogenesis. GIFs are
CC involved in the positive regulation of cell proliferation of lateral
CC organs in a functionally redundant manner. Together with GATA18/HAN,
CC mediates cotyledon identity by preventing ectopic root formation
CC through the repression of PLT1 expression (PubMed:22669825).
CC {ECO:0000269|PubMed:15326298, ECO:0000269|PubMed:15960617,
CC ECO:0000269|PubMed:19392710, ECO:0000269|PubMed:19648231,
CC ECO:0000269|PubMed:21097896, ECO:0000269|PubMed:22669825}.
CC -!- SUBUNIT: Interacts with GRF1, GRF2, GRF5 and GRF9.
CC {ECO:0000269|PubMed:15326298, ECO:0000269|PubMed:15960617}.
CC -!- INTERACTION:
CC Q8L8A5; O81001: GRF1; NbExp=6; IntAct=EBI-1396623, EBI-1396842;
CC Q8L8A5; Q8L8A8: GRF2; NbExp=4; IntAct=EBI-1396623, EBI-1396893;
CC Q8L8A5; Q8L8A7: GRF4; NbExp=3; IntAct=EBI-1396623, EBI-1396671;
CC Q8L8A5; Q8L8A6: GRF5; NbExp=4; IntAct=EBI-1396623, EBI-1396652;
CC Q8L8A5; Q9ZQ12: GRF6; NbExp=3; IntAct=EBI-1396623, EBI-15193797;
CC Q8L8A5; Q8S9M3: GRF9; NbExp=4; IntAct=EBI-1396623, EBI-1396638;
CC Q8L8A5; O82277: TCP10; NbExp=3; IntAct=EBI-1396623, EBI-3133327;
CC Q8L8A5; Q9C9L2: TCP15; NbExp=3; IntAct=EBI-1396623, EBI-4426144;
CC Q8L8A5; Q8LPR5: TCP4; NbExp=3; IntAct=EBI-1396623, EBI-15192325;
CC Q8L8A5; O64647: TCP9; NbExp=3; IntAct=EBI-1396623, EBI-9838721;
CC Q8L8A5; Q9LM84: WOX14; NbExp=3; IntAct=EBI-1396623, EBI-15193011;
CC -!- TISSUE SPECIFICITY: Strongly expressed in actively growing and
CC developing tissues, such as roots, upper stems, and shoot tips and
CC flower buds. Also expressed in mature flowers. Not expressed in the
CC shoot apical meristem (SAM). Highly accumulated in the proximal part of
CC leaf primordia, in the key proliferative zone at the junction region
CC between the leaf blade and leaf petiole. {ECO:0000269|PubMed:15326298,
CC ECO:0000269|PubMed:15960617, ECO:0000269|PubMed:21036927,
CC ECO:0000269|PubMed:21097896, ECO:0000269|PubMed:21880932}.
CC -!- DISRUPTION PHENOTYPE: Small and narrow lateral organs, such as leaves,
CC cotyledons, and flowers. Significant defects in the number of cells in
CC both the leaf blade and leaf petiole (PubMed:22669825,
CC PubMed:19392710). Excessive postmitotic cell enlargement in leaves
CC (compensation phenotype) (PubMed:19392710). Plant missing GIF1/AN3 and
CC OLI2, OLI5 or OLI7 have a strong compensation phenotype
CC (PubMed:19392710). The double mutant an3 han-30 exhibits severe defects
CC in cotyledon development such as ectopic roots formation at the apical
CC region of the embryo and seedlings, and associated with an abnormal
CC expansion of PLT1 expression from the basal embryonic region to the
CC apical region (PubMed:22669825). {ECO:0000269|PubMed:15326298,
CC ECO:0000269|PubMed:15960617, ECO:0000269|PubMed:19392710,
CC ECO:0000269|PubMed:19648231, ECO:0000269|PubMed:21880932,
CC ECO:0000269|PubMed:22669825}.
CC -!- SIMILARITY: Belongs to the SS18 family. {ECO:0000305}.
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DR EMBL; AY102639; AAM52881.1; -; mRNA.
DR EMBL; AF272705; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED93820.1; -; Genomic_DNA.
DR EMBL; BT002848; AAO22666.1; -; mRNA.
DR EMBL; BT004462; AAO42456.1; -; mRNA.
DR RefSeq; NP_198216.2; NM_122747.4.
DR AlphaFoldDB; Q8L8A5; -.
DR SMR; Q8L8A5; -.
DR BioGRID; 18241; 134.
DR IntAct; Q8L8A5; 94.
DR STRING; 3702.AT5G28640.1; -.
DR iPTMnet; Q8L8A5; -.
DR PaxDb; Q8L8A5; -.
DR PRIDE; Q8L8A5; -.
DR ProteomicsDB; 220760; -.
DR EnsemblPlants; AT5G28640.1; AT5G28640.1; AT5G28640.
DR GeneID; 832968; -.
DR Gramene; AT5G28640.1; AT5G28640.1; AT5G28640.
DR KEGG; ath:AT5G28640; -.
DR Araport; AT5G28640; -.
DR TAIR; locus:2148810; AT5G28640.
DR eggNOG; KOG3227; Eukaryota.
DR HOGENOM; CLU_086253_1_0_1; -.
DR InParanoid; Q8L8A5; -.
DR OMA; MYAQPAL; -.
DR OrthoDB; 1495963at2759; -.
DR PhylomeDB; Q8L8A5; -.
DR PRO; PR:Q8L8A5; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8L8A5; baseline and differential.
DR Genevisible; Q8L8A5; AT.
DR GO; GO:0003713; F:transcription coactivator activity; ISS:TAIR.
DR GO; GO:0009955; P:adaxial/abaxial pattern specification; IMP:UniProtKB.
DR GO; GO:0051301; P:cell division; IMP:TAIR.
DR GO; GO:0008283; P:cell population proliferation; IBA:GO_Central.
DR GO; GO:0048825; P:cotyledon development; IMP:UniProtKB.
DR GO; GO:0048366; P:leaf development; IMP:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IPI:TAIR.
DR GO; GO:0010449; P:root meristem growth; IGI:TAIR.
DR InterPro; IPR044779; SS18.
DR InterPro; IPR007726; SS18_N.
DR PANTHER; PTHR23107; PTHR23107; 1.
DR Pfam; PF05030; SSXT; 1.
PE 1: Evidence at protein level;
KW Activator; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..210
FT /note="GRF1-interacting factor 1"
FT /id="PRO_0000419318"
FT REGION 135..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 210 AA; 22464 MW; 4C3FEE1B8C22DE13 CRC64;
MQQHLMQMQP MMAGYYPSNV TSDHIQQYLD ENKSLILKIV ESQNSGKLSE CAENQARLQR
NLMYLAAIAD SQPQPPSVHS QYGSAGGGMI QGEGGSHYLQ QQQATQQQQM TQQSLMAARS
SMLYAQQQQQ QQPYATLQHQ QLHHSQLGMS SSSGGGGSSG LHILQGEAGG FHDFGRGKPE
MGSGGGGEGR GGSSGDGGET LYLKSSDDGN
