ID   GID8_NEMVE              Reviewed;         225 AA.
AC   A7SWD3;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Glucose-induced degradation protein 8 homolog;
GN   ORFNames=v1g247787;
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6;
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- FUNCTION: Core component of the CTLH E3 ubiquitin-protein ligase
CC       complex that mediates ubiquitination and subsequent proteasomal
CC       degradation of target proteins. Acts as a positive regulator of Wnt
CC       signaling pathway by promoting beta-catenin (CTNNB1) nuclear
CC       accumulation. {ECO:0000250|UniProtKB:Q9NWU2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NWU2}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9NWU2}.
CC   -!- SIMILARITY: Belongs to the GID8 family. {ECO:0000305}.
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DR   EMBL; DS469857; EDO31993.1; -; Genomic_DNA.
DR   RefSeq; XP_001624093.1; XM_001624043.1.
DR   AlphaFoldDB; A7SWD3; -.
DR   SMR; A7SWD3; -.
DR   STRING; 45351.EDO31993; -.
DR   EnsemblMetazoa; EDO31993; EDO31993; NEMVEDRAFT_v1g247787.
DR   GeneID; 5502962; -.
DR   KEGG; nve:5502962; -.
DR   eggNOG; KOG2659; Eukaryota.
DR   HOGENOM; CLU_073203_1_0_1; -.
DR   InParanoid; A7SWD3; -.
DR   OMA; QNGRIQE; -.
DR   OrthoDB; 1365635at2759; -.
DR   PhylomeDB; A7SWD3; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR013144; CRA_dom.
DR   InterPro; IPR024964; CTLH/CRA.
DR   InterPro; IPR006595; CTLH_C.
DR   InterPro; IPR006594; LisH.
DR   Pfam; PF10607; CLTH; 1.
DR   Pfam; PF08513; LisH; 1.
DR   SMART; SM00757; CRA; 1.
DR   SMART; SM00668; CTLH; 1.
DR   SMART; SM00667; LisH; 1.
DR   PROSITE; PS50897; CTLH; 1.
DR   PROSITE; PS50896; LISH; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Wnt signaling pathway.
FT   CHAIN           1..225
FT                   /note="Glucose-induced degradation protein 8 homolog"
FT                   /id="PRO_0000328506"
FT   DOMAIN          22..54
FT                   /note="LisH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT   DOMAIN          60..117
FT                   /note="CTLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00058"
SQ   SEQUENCE   225 AA;  25891 MW;  50DF10C0AB634284 CRC64;
     MSFAEEVNRE EWMEKIGKLR FQRAEMNRLI MDYLVTEGYK EAAEKFRIES GTQPTAPLDS
     LDDRIKIREA VQKGDLEQAV SMTNKLNPDI LDSNQQLYFH LQQQRLIELI REKDIEAAVE
     FAQGQFSEQG QESGRYLEEL EQTMALLAFD NPEESPFGDL LHTSQRQKVA SELNAAILEA
     EHKKTQPKLA NVLKLLLWAQ DELEGKKVKF PKMAEIASGT FEESR