ID   GFI1B_XENLA             Reviewed;         343 AA.
AC   Q6DCW1;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Zinc finger protein Gfi-1b;
DE   AltName: Full=Growth factor independent protein 1B;
GN   Name=gfi1b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential transcriptional regulator necessary for development
CC       and differentiation of erythroid and megakaryocytic lineages. Alters
CC       histone methylation by recruiting histone methyltransferase to target
CC       genes promoters. Plays a role in heterochromatin formation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The zinc finger domain is essential for erythroid expansion and
CC       acts as an activation domain whereas non finger domain serves as
CC       repression domain. {ECO:0000250}.
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DR   EMBL; BC077878; AAH77878.1; -; mRNA.
DR   RefSeq; NP_001087000.1; NM_001093531.1.
DR   AlphaFoldDB; Q6DCW1; -.
DR   SMR; Q6DCW1; -.
DR   DNASU; 446835; -.
DR   GeneID; 446835; -.
DR   KEGG; xla:446835; -.
DR   CTD; 446835; -.
DR   Xenbase; XB-GENE-944429; gfi1b.L.
DR   OrthoDB; 1318335at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 446835; Expressed in liver and 11 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 4.
DR   SMART; SM00355; ZnF_C2H2; 6.
DR   SUPFAM; SSF57667; SSF57667; 4.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; Developmental protein; DNA-binding; Metal-binding;
KW   Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..343
FT                   /note="Zinc finger protein Gfi-1b"
FT                   /id="PRO_0000306330"
FT   ZN_FING         176..199
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         205..227
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         233..255
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         261..283
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         289..311
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         317..340
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..20
FT                   /note="Mediates repression of transcription"
FT                   /evidence="ECO:0000250"
FT   REGION          1..20
FT                   /note="SNAG domain"
FT                   /evidence="ECO:0000250"
FT   REGION          51..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..77
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   343 AA;  39227 MW;  77ACD7B606B79FD1 CRC64;
     MPRSFLVKSK KTHTYNQHRY VEEQPVTGVD LVATVYHAHC TECPAEFPAF STDPTEKQHT
     PENVITEEAR SDPGDPREKI PFLSRSISPN SFQGIALSSM RPLKHYDPSP LSAFYTQNFS
     WDALHSTYGF KQIPSHIHPS MLQNSINLYS CPPRVDSDSD HPINYSMSYS PKMDTYHCVK
     CSKVFSTSHG LEVHVRRSHS GTRPFVCNIC GKSFGHAVSL EQHLNVHSQE RSFECKMCGK
     TFKRSSTLST HLLIHSDTRP YPCQFCGKRF HQKSDMKKHT YIHTGEKPHK CQVCGKAFSQ
     SSNLITHSRK HTGFKPFSCD LCCKGFQRKV DLRRHRENQH GLK