GEP7_YEAST
ID GEP7_YEAST Reviewed; 287 AA.
AC P53171; D6VU84;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Genetic interactor of prohibitin 7, mitochondrial;
DE Flags: Precursor;
GN Name=GEP7; OrderedLocusNames=YGL057C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9234674;
RX DOI=10.1002/(sici)1097-0061(199707)13:9<861::aid-yea125>3.0.co;2-9;
RA Feuermann M., de Montigny J., Potier S., Souciet J.-L.;
RT "The characterization of two new clusters of duplicated genes suggests a
RT 'Lego' organization of the yeast Saccharomyces cerevisiae chromosomes.";
RL Yeast 13:861-869(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=16823961; DOI=10.1021/pr050477f;
RA Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.;
RT "Toward the complete yeast mitochondrial proteome: multidimensional
RT separation techniques for mitochondrial proteomics.";
RL J. Proteome Res. 5:1543-1554(2006).
RN [6]
RP FUNCTION.
RX PubMed=18245340; DOI=10.1534/genetics.107.083055;
RA Frederick R.L., Okamoto K., Shaw J.M.;
RT "Multiple pathways influence mitochondrial inheritance in budding yeast.";
RL Genetics 178:825-837(2008).
RN [7]
RP FUNCTION.
RX PubMed=19221197; DOI=10.1083/jcb.200810189;
RA Osman C., Haag M., Potting C., Rodenfels J., Dip P.V., Wieland F.T.,
RA Brugger B., Westermann B., Langer T.;
RT "The genetic interactome of prohibitins: coordinated control of cardiolipin
RT and phosphatidylethanolamine by conserved regulators in mitochondria.";
RL J. Cell Biol. 184:583-596(2009).
CC -!- FUNCTION: Involved in respiratory growth and required for cell survival
CC in the absence of prohibitins or GEM1. {ECO:0000269|PubMed:18245340,
CC ECO:0000269|PubMed:19221197}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16823961}; Single-pass
CC membrane protein {ECO:0000269|PubMed:14562095,
CC ECO:0000269|PubMed:16823961}.
CC -!- SIMILARITY: Belongs to the GEP7 family. {ECO:0000305}.
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DR EMBL; Z72579; CAA96760.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA08045.1; -; Genomic_DNA.
DR PIR; S64061; S64061.
DR RefSeq; NP_011458.1; NM_001180922.1.
DR AlphaFoldDB; P53171; -.
DR BioGRID; 33190; 167.
DR DIP; DIP-2071N; -.
DR IntAct; P53171; 2.
DR MINT; P53171; -.
DR STRING; 4932.YGL057C; -.
DR MaxQB; P53171; -.
DR PaxDb; P53171; -.
DR PRIDE; P53171; -.
DR EnsemblFungi; YGL057C_mRNA; YGL057C; YGL057C.
DR GeneID; 852823; -.
DR KEGG; sce:YGL057C; -.
DR SGD; S000003025; GEP7.
DR VEuPathDB; FungiDB:YGL057C; -.
DR HOGENOM; CLU_064141_0_0_1; -.
DR InParanoid; P53171; -.
DR OMA; LPFIEYN; -.
DR BioCyc; YEAST:G3O-30565-MON; -.
DR PRO; PR:P53171; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P53171; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Reference proteome; Transit peptide;
KW Transmembrane; Transmembrane helix.
FT TRANSIT 1..24
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 25..287
FT /note="Genetic interactor of prohibitin 7, mitochondrial"
FT /id="PRO_0000202766"
FT TRANSMEM 250..266
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 287 AA; 32959 MW; B66F4E68AE681365 CRC64;
MVLSNVKIFR LKSHRAFRIG PMIKAVAGNL LVKRFYQPKL ERIPPASLLL KQKIRLAQNG
STTSTENPIS FSQTMSEIFS VLQPSAPDLD EDETSGLKRD HLLTERLNNG ELGVIMNKFF
NPSSTHNNQL IDTNILLQNF PKLSGNDLDL LDFAINEKMR GNWNDLKQDF IQLWYYKSFG
FLGPRTQFVL TNSSPSVRSQ FLKLPFIEYN WFLLQNNKNA NILPADVQNV VKVFHLDDKR
FTWKSIDPFS KAIISFVVFV SIYVWLDESA KQKTKELPAQ KSTVISE
