ID   GEP7_LACTC              Reviewed;         302 AA.
AC   C5E2Q0;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Genetic interactor of prohibitin 7, mitochondrial;
DE   Flags: Precursor;
GN   Name=GEP7; OrderedLocusNames=KLTH0H06754g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Involved in respiratory growth and required for cell survival
CC       in the absence of prohibitins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GEP7 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CU928180; CAR30311.1; -; Genomic_DNA.
DR   RefSeq; XP_002556173.1; XM_002556127.1.
DR   AlphaFoldDB; C5E2Q0; -.
DR   EnsemblFungi; CAR30311; CAR30311; KLTH0H06754g.
DR   GeneID; 8294489; -.
DR   KEGG; lth:KLTH0H06754g; -.
DR   eggNOG; ENOG502S4Y0; Eukaryota.
DR   HOGENOM; CLU_094335_0_0_1; -.
DR   InParanoid; C5E2Q0; -.
DR   OMA; ERLTNIN; -.
DR   OrthoDB; 1311594at2759; -.
DR   Proteomes; UP000002036; Chromosome H.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix.
FT   TRANSIT         1..21
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..302
FT                   /note="Genetic interactor of prohibitin 7, mitochondrial"
FT                   /id="PRO_0000399739"
FT   TRANSMEM        236..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          20..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          264..290
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        269..290
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   302 AA;  34726 MW;  7C0D5B275E9306D7 CRC64;
     MLSQYLRKHH LLSRRHQFMR CASQSRSPPR SLLQRQAKRR GEAEAVAPSQ LIVTSLKDIF
     STFQPSGFTQ EDDELEAVKQ REDAMQRLEN GELRELLLHK FGARRIPSTT ETGNSVGDLR
     IPPRNINQAF HNLTTQEREL IEVFQSLGTP SMNWRDVPLV SKQLQFYISF GSYGPREGIT
     FLGSKPEDFI WSKTSRRLLP GQTVRKLPKD ATTNTWTCIP SRKANFERMK KGLDPGTRII
     AWLGILIVMI ASVRDYKQRR DSEATVKVSE FTEQETSEPQ AAQQDTAPIS KTPKSWYQFW
     KS