ID   GEP7_CLAL4              Reviewed;         263 AA.
AC   C4XVW1;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Genetic interactor of prohibitin 7, mitochondrial;
DE   Flags: Precursor;
GN   Name=GEP7; ORFNames=CLUG_00084;
OS   Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Metschnikowiaceae; Clavispora.
OX   NCBI_TaxID=306902;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42720;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Involved in respiratory growth and required for cell survival
CC       in the absence of prohibitins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GEP7 family. {ECO:0000305}.
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DR   EMBL; CH408076; EEQ35961.1; -; Genomic_DNA.
DR   RefSeq; XP_002618925.1; XM_002618879.1.
DR   AlphaFoldDB; C4XVW1; -.
DR   SMR; C4XVW1; -.
DR   EnsemblFungi; EEQ35961; EEQ35961; CLUG_00084.
DR   GeneID; 8500201; -.
DR   KEGG; clu:CLUG_00084; -.
DR   VEuPathDB; FungiDB:CLUG_00084; -.
DR   HOGENOM; CLU_080217_0_0_1; -.
DR   InParanoid; C4XVW1; -.
DR   OMA; VTKTFIY; -.
DR   Proteomes; UP000007703; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005751; C:mitochondrial respiratory chain complex IV; IEA:InterPro.
DR   GO; GO:0006123; P:mitochondrial electron transport, cytochrome c to oxygen; IEA:InterPro.
DR   Gene3D; 1.10.442.10; -; 1.
DR   InterPro; IPR004203; Cyt_c_oxidase_su4_fam.
DR   InterPro; IPR036639; Cyt_c_oxidase_su4_sf.
DR   PANTHER; PTHR10707; PTHR10707; 1.
DR   Pfam; PF02936; COX4; 1.
DR   SUPFAM; SSF81406; SSF81406; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix.
FT   TRANSIT         1..26
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..263
FT                   /note="Genetic interactor of prohibitin 7, mitochondrial"
FT                   /id="PRO_0000399738"
FT   TRANSMEM        188..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          232..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   263 AA;  30569 MW;  84369B4749FE03F7 CRC64;
     MSLAMLTRNM LRRTSVRAFA SSASNFTAGK DSARKLSPEE AKAEAAKLAI QSLKDVGSVF
     SSGSDDAVQP IDTRPVFENP ELFGTLNLLH QGQVLKELQE KYDKNWNKLT DEEKKLGYYI
     AYGNWGPREK FINWNTQEAP YDLPFRVPSK VRLSNPQAND VVHKLEPLYL SETPVRKEQF
     DTSKMDPVTK TFIYITLFVM LFAISRDKNT GESGKPQEII IEDRYMKSKL EKEQKEKEKE
     IEEENRKNQE KQARRKWYYL WLK