ID   GEP5_ZYGRC              Reviewed;         277 AA.
AC   C5DSN0;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Genetic interactor of prohibitin 5, mitochondrial;
DE   AltName: Full=Required for respiratory growth protein 5;
GN   Name=GEP5; Synonyms=RRG5; OrderedLocusNames=ZYRO0C01562g;
OS   Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568
OS   / NRRL Y-229) (Candida mogii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX   NCBI_TaxID=559307;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2623 / CBS 732 / BCRC 21506 / NBRC 1130 / NCYC 568 / NRRL
RC   Y-229;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Essential for respiratory growth and required for maintenance
CC       of mtDNA. Required for cell survival in the absence of prohibitins (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GEP5 family. {ECO:0000305}.
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DR   EMBL; CU928175; CAR26791.1; -; Genomic_DNA.
DR   RefSeq; XP_002495724.1; XM_002495679.1.
DR   AlphaFoldDB; C5DSN0; -.
DR   STRING; 559307.C5DSN0; -.
DR   EnsemblFungi; CAR26791; CAR26791; ZYRO0C01562g.
DR   GeneID; 8202916; -.
DR   KEGG; zro:ZYRO0C01562g; -.
DR   HOGENOM; CLU_079415_0_0_1; -.
DR   InParanoid; C5DSN0; -.
DR   Proteomes; UP000008536; Chromosome C.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IEA:InterPro.
DR   InterPro; IPR031455; Gep5.
DR   Pfam; PF17053; GEP5; 1.
PE   3: Inferred from homology;
KW   Mitochondrion; Reference proteome.
FT   CHAIN           1..277
FT                   /note="Genetic interactor of prohibitin 5, mitochondrial"
FT                   /id="PRO_0000399692"
SQ   SEQUENCE   277 AA;  32970 MW;  A4EA28318BAEC0FE CRC64;
     MVSSNLQELI PALSRSIRQL PLHIETQKVL EFYCRNSSYK SLLVAQDISE FEKHNDHKYL
     EALIQKTHFL WDNPLPPFLK RFQLYHKELT NHWPYEYQRS LLSMSNPRKE SQGYLWRDGK
     ELALSNLRFE KHRWADENII ERLSPEQGTQ LLHSIFHQYF FLKSHARLCY NNRKIPVPIV
     EIPLRPMGND VADCRIRNLF KRKTAVVWNL LAWENRPLST RNEQLLGEII TKSETRSMRR
     LYQRASRRAY VVTNEGKDPN GLQVPEFRPG EILQMSI