GEP5_YEAST
ID GEP5_YEAST Reviewed; 293 AA.
AC Q12393; D6VY91;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Genetic interactor of prohibitin 5, mitochondrial;
DE AltName: Full=Required for respiratory growth protein 5;
GN Name=GEP5; Synonyms=RRG5; OrderedLocusNames=YLR091W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 76625 / YPH499;
RX PubMed=14576278; DOI=10.1073/pnas.2135385100;
RA Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E.,
RA Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P.,
RA Pfanner N., Meisinger C.;
RT "The proteome of Saccharomyces cerevisiae mitochondria.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003).
RN [6]
RP FUNCTION.
RX PubMed=19751518; DOI=10.1186/gb-2009-10-9-r95;
RA Merz S., Westermann B.;
RT "Genome-wide deletion mutant analysis reveals genes required for
RT respiratory growth, mitochondrial genome maintenance and mitochondrial
RT protein synthesis in Saccharomyces cerevisiae.";
RL Genome Biol. 10:R95.1-R95.18(2009).
RN [7]
RP FUNCTION.
RX PubMed=19221197; DOI=10.1083/jcb.200810189;
RA Osman C., Haag M., Potting C., Rodenfels J., Dip P.V., Wieland F.T.,
RA Brugger B., Westermann B., Langer T.;
RT "The genetic interactome of prohibitins: coordinated control of cardiolipin
RT and phosphatidylethanolamine by conserved regulators in mitochondria.";
RL J. Cell Biol. 184:583-596(2009).
CC -!- FUNCTION: Essential for respiratory growth and required for maintenance
CC of mtDNA. Required for cell survival in the absence of prohibitins.
CC {ECO:0000269|PubMed:19221197, ECO:0000269|PubMed:19751518}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14562095,
CC ECO:0000269|PubMed:14576278}.
CC -!- SIMILARITY: Belongs to the GEP5 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U53880; AAB67595.1; -; Genomic_DNA.
DR EMBL; Z73263; CAA97652.1; -; Genomic_DNA.
DR EMBL; AY692636; AAT92655.1; -; Genomic_DNA.
DR EMBL; BK006945; DAA09407.1; -; Genomic_DNA.
DR PIR; S64925; S64925.
DR RefSeq; NP_013192.1; NM_001181978.1.
DR AlphaFoldDB; Q12393; -.
DR BioGRID; 31364; 163.
DR IntAct; Q12393; 1.
DR MINT; Q12393; -.
DR STRING; 4932.YLR091W; -.
DR MaxQB; Q12393; -.
DR PaxDb; Q12393; -.
DR PRIDE; Q12393; -.
DR EnsemblFungi; YLR091W_mRNA; YLR091W; YLR091W.
DR GeneID; 850780; -.
DR KEGG; sce:YLR091W; -.
DR SGD; S000004081; GEP5.
DR VEuPathDB; FungiDB:YLR091W; -.
DR eggNOG; ENOG502S2Q8; Eukaryota.
DR HOGENOM; CLU_079415_0_0_1; -.
DR InParanoid; Q12393; -.
DR OMA; IVEIPMK; -.
DR BioCyc; YEAST:G3O-32241-MON; -.
DR PRO; PR:Q12393; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; Q12393; protein.
DR GO; GO:0099617; C:matrix side of mitochondrial inner membrane; IDA:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0000002; P:mitochondrial genome maintenance; IMP:SGD.
DR GO; GO:0097745; P:mitochondrial tRNA 5'-end processing; IMP:SGD.
DR InterPro; IPR031455; Gep5.
DR Pfam; PF17053; GEP5; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome.
FT CHAIN 1..293
FT /note="Genetic interactor of prohibitin 5, mitochondrial"
FT /id="PRO_0000247349"
SQ SEQUENCE 293 AA; 33868 MW; E06366A5512EC96C CRC64;
MASQVNALLL PVIESTPLHQ ITKVALTTTL TSKQSDYKFK EIAVPLTKSL QLYEKAQRRQ
DLRASLKALE SIIYQTHFQW NNPLPRHAHL FQKHYHFLLT HWPFENHRDL VDSIAVNNGK
LNSTSSRSVW LKADWITLFN VKNPWVQTPP SLMRLSGTDL DTFTPERIFL INSLGNHYKF
LIANSHLSYN HKKYPSPGVQ IPVRNALGEV SPAKQIAQLF ARQLSHIYKS LFIENPPLSP
ENELALTAVF YDETVERRLR RLYMRACARA YTTTNADSTT EPLMFHCTRW EVD
