ID   GEP5_VANPO              Reviewed;         281 AA.
AC   A7TRR5;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Genetic interactor of prohibitin 5, mitochondrial;
DE   AltName: Full=Required for respiratory growth protein 5;
GN   Name=GEP5; Synonyms=RRG5; ORFNames=Kpol_392p4;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Essential for respiratory growth and required for maintenance
CC       of mtDNA. Required for cell survival in the absence of prohibitins (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GEP5 family. {ECO:0000305}.
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DR   EMBL; DS480486; EDO15037.1; -; Genomic_DNA.
DR   RefSeq; XP_001642895.1; XM_001642845.1.
DR   AlphaFoldDB; A7TRR5; -.
DR   STRING; 436907.A7TRR5; -.
DR   EnsemblFungi; EDO15037; EDO15037; Kpol_392p4.
DR   GeneID; 5543083; -.
DR   KEGG; vpo:Kpol_392p4; -.
DR   eggNOG; ENOG502S2Q8; Eukaryota.
DR   HOGENOM; CLU_079415_0_0_1; -.
DR   InParanoid; A7TRR5; -.
DR   OMA; IVEIPMK; -.
DR   OrthoDB; 1226220at2759; -.
DR   PhylomeDB; A7TRR5; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IEA:InterPro.
DR   InterPro; IPR031455; Gep5.
DR   Pfam; PF17053; GEP5; 1.
PE   3: Inferred from homology;
KW   Mitochondrion; Reference proteome.
FT   CHAIN           1..281
FT                   /note="Genetic interactor of prohibitin 5, mitochondrial"
FT                   /id="PRO_0000399687"
SQ   SEQUENCE   281 AA;  33495 MW;  8A020C4420013CBA CRC64;
     MTSVKDLGKR LKPILLESLE RLPLHKPTLD ILERRIHVAD LPFMEEYVGI LNEYEISKIN
     SKVENESRAL EKIVKKTHIV WNNDKFPNHL EKFKNHYMEL LHHWPYEFHS DVLNMARPGT
     GSLIYLCLNN DDRFFNFYKS QINNKWFNSV DQYKLTDEQR VSIYNDIFKQ IFFLKRHTTI
     SEVNKNMVPI VEVPLKPIGC DIPACRIKNL FNKKVDYIWK LLSLSSPAIS LSHEKIIMNI
     LEDTKDNRRI NRLYRRSLKN SYVFDDTNPI EITYRYASFL Q