ID   GEP5_LACTC              Reviewed;         267 AA.
AC   C5DN25;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Genetic interactor of prohibitin 5, mitochondrial;
DE   AltName: Full=Required for respiratory growth protein 5;
GN   Name=GEP5; Synonyms=RRG5; OrderedLocusNames=KLTH0G13596g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Essential for respiratory growth and required for maintenance
CC       of mtDNA. Required for cell survival in the absence of prohibitins (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GEP5 family. {ECO:0000305}.
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DR   EMBL; CU928171; CAR25186.1; -; Genomic_DNA.
DR   RefSeq; XP_002555623.1; XM_002555577.1.
DR   AlphaFoldDB; C5DN25; -.
DR   STRING; 559295.C5DN25; -.
DR   EnsemblFungi; CAR25186; CAR25186; KLTH0G13596g.
DR   GeneID; 8293906; -.
DR   KEGG; lth:KLTH0G13596g; -.
DR   eggNOG; ENOG502S2Q8; Eukaryota.
DR   HOGENOM; CLU_079415_0_0_1; -.
DR   InParanoid; C5DN25; -.
DR   OMA; IVEIPMK; -.
DR   OrthoDB; 1226220at2759; -.
DR   Proteomes; UP000002036; Chromosome G.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IEA:InterPro.
DR   InterPro; IPR031455; Gep5.
DR   Pfam; PF17053; GEP5; 1.
PE   3: Inferred from homology;
KW   Mitochondrion; Reference proteome.
FT   CHAIN           1..267
FT                   /note="Genetic interactor of prohibitin 5, mitochondrial"
FT                   /id="PRO_0000399686"
SQ   SEQUENCE   267 AA;  31397 MW;  73897C19FD2CCB52 CRC64;
     MNMAVRALEK LPLDIRTLEL LERKLLKKSL PGFQELAQQY TADGSSKSLE SIVHLTYFHW
     CNEDAPHIKK FREHYAELRD HWPYEFHRSI LSMDTPKTQS IRFLWSSNSP KVLSKMSYEK
     YAHDTEERPS RLTELQRTVQ FHEVFQHFLF LKSRPHLCKT RKGLAVPIVE IPMKPLGQNI
     PEVRVRNLFK RKIAYVWKVL ALDSPALSRQ NELSLAKIID SPQLPEDVSS KRELKRLYQR
     ACRGAYTIEQ HPVLGLEIKE SKLLKRL