ID   GEP5_KLULA              Reviewed;         305 AA.
AC   Q6CJE6;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Genetic interactor of prohibitin 5, mitochondrial;
DE   AltName: Full=Required for respiratory growth protein 5;
GN   Name=GEP5; Synonyms=RRG5; OrderedLocusNames=KLLA0F19228g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Essential for respiratory growth and required for maintenance
CC       of mtDNA. Required for cell survival in the absence of prohibitins (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GEP5 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98651.1; -; Genomic_DNA.
DR   RefSeq; XP_455943.1; XM_455943.1.
DR   AlphaFoldDB; Q6CJE6; -.
DR   STRING; 28985.XP_455943.1; -.
DR   EnsemblFungi; CAG98651; CAG98651; KLLA0_F19228g.
DR   GeneID; 2895537; -.
DR   KEGG; kla:KLLA0_F19228g; -.
DR   eggNOG; ENOG502S2Q8; Eukaryota.
DR   HOGENOM; CLU_079415_0_0_1; -.
DR   InParanoid; Q6CJE6; -.
DR   OMA; IVEIPMK; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IEA:InterPro.
DR   InterPro; IPR031455; Gep5.
DR   Pfam; PF17053; GEP5; 1.
PE   3: Inferred from homology;
KW   Mitochondrion; Reference proteome.
FT   CHAIN           1..305
FT                   /note="Genetic interactor of prohibitin 5, mitochondrial"
FT                   /id="PRO_0000399685"
SQ   SEQUENCE   305 AA;  35473 MW;  AD671D5A06510232 CRC64;
     MKASLLRTSK LYKGLHSITK DAISKVDTFP KNKQHETLHR LNSFNENPTR KTLEKLVYSV
     HFHLLNDPPK HVDILRQYPN ELAKFWPYEM QHSILEMDDP NLTSQTILWS RNNKDALDFL
     SFNRHKWLRP KNWQTPNEEL IKDITGIDGL QSTQITEVLR LPAEKIKETL RQIFEHYYFL
     KTNPKLCATK KLQAPIVEIG MKPDGFDIAD IRIDNLFKKK VKLISDLLYS QNPVLTSDAE
     SILTSIVNDP DLNRRTKRLY KNVASRSYLF KDGKFEISEL ARGGFVLSKE NLSENLAAAL
     EEEHN