ID   GEP5_ASHGO              Reviewed;         266 AA.
AC   Q74ZX6;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Genetic interactor of prohibitin 5, mitochondrial;
DE   AltName: Full=Required for respiratory growth protein 5;
GN   Name=GEP5; Synonyms=RRG5; OrderedLocusNames=AGR082C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Essential for respiratory growth and required for maintenance
CC       of mtDNA. Required for cell survival in the absence of prohibitins (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GEP5 family. {ECO:0000305}.
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DR   EMBL; AE016820; AAS54571.1; -; Genomic_DNA.
DR   RefSeq; NP_986747.1; NM_211809.1.
DR   AlphaFoldDB; Q74ZX6; -.
DR   STRING; 33169.AAS54571; -.
DR   EnsemblFungi; AAS54571; AAS54571; AGOS_AGR082C.
DR   GeneID; 4623049; -.
DR   KEGG; ago:AGOS_AGR082C; -.
DR   eggNOG; ENOG502S2Q8; Eukaryota.
DR   HOGENOM; CLU_079415_0_0_1; -.
DR   InParanoid; Q74ZX6; -.
DR   OMA; IVEIPMK; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IEA:InterPro.
DR   InterPro; IPR031455; Gep5.
DR   Pfam; PF17053; GEP5; 1.
PE   3: Inferred from homology;
KW   Mitochondrion; Reference proteome.
FT   CHAIN           1..266
FT                   /note="Genetic interactor of prohibitin 5, mitochondrial"
FT                   /id="PRO_0000399683"
SQ   SEQUENCE   266 AA;  31914 MW;  9825CB09CB51DE38 CRC64;
     MNEHIQRIVS RLPLHRATSE VILAYLSKQQ AQYPTERIEL VEPLNDFLRK GGHQGLQRLV
     FHVHFQLMLR APEHLRLLRR HREELQRFWP YERHHSLLAL SDVRSQSLRR LWEDGQEEVL
     QQMQYCRHHW LREGDVPERY ALTQAQREEV LHRVFAQYMF LKQRPALWSV RRLPIPVVEI
     GMTPLGFDIP DVRVDGLFKD KTKSVLRLLY REHPALTPAA EEDMLRIIAE CPTRAMRRIY
     LRACRRAYVL DADAQLFRVS RLRHFI