ID   GEP3_YEAST              Reviewed;         556 AA.
AC   Q08622; D6W2R1;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 142.
DE   RecName: Full=Genetic interactor of prohibitins 3, mitochondrial;
DE   AltName: Full=Altered inheritance of mitochondria protein 40;
DE   AltName: Full=Found in mitochondrial proteome protein 38;
DE   Flags: Precursor;
GN   Name=GEP3; Synonyms=AIM40, FMP48; OrderedLocusNames=YOR205C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169874;
RA   Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA   Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA   Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA   Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA   Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA   Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA   Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA   Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA   Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA   Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA   Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA   Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA   Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA   Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA   Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA   Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA   Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL   Nature 387:98-102(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [4]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [5]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 76625 / YPH499;
RX   PubMed=14576278; DOI=10.1073/pnas.2135385100;
RA   Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E.,
RA   Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P.,
RA   Pfanner N., Meisinger C.;
RT   "The proteome of Saccharomyces cerevisiae mitochondria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003).
RN   [6]
RP   DISRUPTION PHENOTYPE, AND FUNCTION.
RX   PubMed=19751518; DOI=10.1186/gb-2009-10-9-r95;
RA   Merz S., Westermann B.;
RT   "Genome-wide deletion mutant analysis reveals genes required for
RT   respiratory growth, mitochondrial genome maintenance and mitochondrial
RT   protein synthesis in Saccharomyces cerevisiae.";
RL   Genome Biol. 10:R95.1-R95.18(2009).
RN   [7]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=19300474; DOI=10.1371/journal.pgen.1000407;
RA   Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J.,
RA   Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M.,
RA   Troyanskaya O.G., Caudy A.A.;
RT   "Computationally driven, quantitative experiments discover genes required
RT   for mitochondrial biogenesis.";
RL   PLoS Genet. 5:E1000407-E1000407(2009).
CC   -!- FUNCTION: Interacts genetically with prohibitins and thus may be
CC       involved in the mitochondrial lipid metabolism.
CC       {ECO:0000269|PubMed:19751518}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14562095,
CC       ECO:0000269|PubMed:14576278}.
CC   -!- DISRUPTION PHENOTYPE: Increases frequency of mitochondrial genome loss.
CC       {ECO:0000269|PubMed:19300474, ECO:0000269|PubMed:19751518}.
CC   -!- MISCELLANEOUS: Present with 937 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class YlqF/YawG GTPase family. GEP3
CC       subfamily. {ECO:0000255|PROSITE-ProRule:PRU01058}.
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DR   EMBL; Z75113; CAA99420.1; -; Genomic_DNA.
DR   EMBL; BK006948; DAA10977.1; -; Genomic_DNA.
DR   PIR; S67097; S67097.
DR   RefSeq; NP_014848.1; NM_001183624.1.
DR   AlphaFoldDB; Q08622; -.
DR   SMR; Q08622; -.
DR   BioGRID; 34600; 455.
DR   DIP; DIP-6701N; -.
DR   IntAct; Q08622; 6.
DR   STRING; 4932.YOR205C; -.
DR   MaxQB; Q08622; -.
DR   PaxDb; Q08622; -.
DR   PRIDE; Q08622; -.
DR   EnsemblFungi; YOR205C_mRNA; YOR205C; YOR205C.
DR   GeneID; 854380; -.
DR   KEGG; sce:YOR205C; -.
DR   SGD; S000005731; GEP3.
DR   VEuPathDB; FungiDB:YOR205C; -.
DR   eggNOG; ENOG502S0UP; Eukaryota.
DR   HOGENOM; CLU_025792_1_0_1; -.
DR   InParanoid; Q08622; -.
DR   OMA; QIVKYIP; -.
DR   BioCyc; YEAST:G3O-33709-MON; -.
DR   PRO; PR:Q08622; -.
DR   Proteomes; UP000002311; Chromosome XV.
DR   RNAct; Q08622; protein.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IDA:SGD.
DR   GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0030490; P:maturation of SSU-rRNA; IMP:SGD.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR030378; G_CP_dom.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01926; MMR_HSR1; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51721; G_CP; 1.
PE   1: Evidence at protein level;
KW   Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..21
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..556
FT                   /note="Genetic interactor of prohibitins 3, mitochondrial"
FT                   /id="PRO_0000237640"
FT   DOMAIN          113..305
FT                   /note="CP-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01058"
SQ   SEQUENCE   556 AA;  63853 MW;  57F2AFF434828F84 CRC64;
     MLNLCHALRG VRQFSCSVIV KVKCASCSIK LQDQDPSKPG YYTKPKSLPD SKLNPDLQDL
     KYLLFSQDIQ LSKQATQNDP DLKTKRDLLL RVICKRCSNA LHHNNYNPEE FPESTLNDIL
     NYVPRGSNVM HIVPFVEFPL HLDPNVLKRN DLDTTLVLTK SDQVFKDKNA VSKKVPIFMK
     QFLKNTLRID SNKTFAISAL KNWNISMFYN YFKNYTYLLG NPNVGKSTLI NTLLQKYLGY
     KVKIDSTGKI NSPSEEVMQE AFTNPKNFFK IQAAGVSHIP NLTRSVQAYQ VGGKILFDLP
     GYSTSTSRLR LEELIDERWL QRLRKTDLFN RKHIKQKTYE SMKGTSQGGC YTVGGIFYLV
     PPKGSINQIV KYIPGPSKTF KNIEKGIDVF NSCNSSSGTH PLSRYCGIKS VICEKSQYKR
     YAIPPFIGSI EIVLKDIGYI LLRTTGRYEF KGLHEIWIPR GIQVGIREPL ENLIESGYQR
     YIETNGKESS CPRDRPIISS LYEMAPDEAD TLNAVKKSYL EKTEKDLSAR RFVDDDPYDL
     VQHLEKKKNP YWYYQW