GDX_YERPS
ID GDX_YERPS Reviewed; 104 AA.
AC Q66FD1;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Guanidinium exporter {ECO:0000250|UniProtKB:P69937};
GN Name=gdx {ECO:0000250|UniProtKB:P69937}; Synonyms=sugE;
GN OrderedLocusNames=YPTB0409;
OS Yersinia pseudotuberculosis serotype I (strain IP32953).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=273123;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IP32953;
RX PubMed=15358858; DOI=10.1073/pnas.0404012101;
RA Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O.,
RA Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L.,
RA Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C.,
RA Simonet M., Chenal-Francisque V., Souza B., Dacheux D., Elliott J.M.,
RA Derbise A., Hauser L.J., Garcia E.;
RT "Insights into the evolution of Yersinia pestis through whole-genome
RT comparison with Yersinia pseudotuberculosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004).
CC -!- FUNCTION: Guanidinium ion exporter. Couples guanidinium export to the
CC proton motive force, exchanging one guanidinium ion for two protons.
CC {ECO:0000250|UniProtKB:P69937}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P69937}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P69937}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
CC Gdx/SugE subfamily. {ECO:0000305}.
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DR EMBL; BX936398; CAH19649.1; -; Genomic_DNA.
DR RefSeq; WP_002228124.1; NZ_CP009712.1.
DR AlphaFoldDB; Q66FD1; -.
DR SMR; Q66FD1; -.
DR EnsemblBacteria; CAH19649; CAH19649; YPTB0409.
DR GeneID; 66843177; -.
DR KEGG; ypo:BZ17_2160; -.
DR KEGG; yps:YPTB0409; -.
DR PATRIC; fig|273123.14.peg.2285; -.
DR OMA; FEIAWAI; -.
DR Proteomes; UP000001011; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR InterPro; IPR000390; Small_drug/metabolite_transptr.
DR InterPro; IPR045324; Small_multidrug_res.
DR PANTHER; PTHR30561; PTHR30561; 1.
DR Pfam; PF00893; Multi_Drug_Res; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Ion transport; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..104
FT /note="Guanidinium exporter"
FT /id="PRO_0000108109"
FT TOPO_DOM 1
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 2..19
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 20..28
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..77
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..81
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..104
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 104 AA; 10651 MW; 6DADB41E0B97B5BB CRC64;
MAWIILVIAG LLEVIWAIGL KYSHGFSRLT PSIITLVAMA ASVFLLAYAM KSLPAGTAYA
VWTGIGAVGT AILGIVLLGE SASLARILSL GLILAGIIGL KLAS
