ALMT9_ARATH
ID ALMT9_ARATH Reviewed; 598 AA.
AC Q9LS46;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Aluminum-activated malate transporter 9;
DE Short=AtALMT9;
GN Name=ALMT9; OrderedLocusNames=At3g18440; ORFNames=MYF24.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16740662; DOI=10.1073/pnas.0602868103;
RA Hoekenga O.A., Maron L.G., Pineros M.A., Cancado G.M., Shaff J.,
RA Kobayashi Y., Ryan P.R., Dong B., Delhaize E., Sasaki T., Matsumoto H.,
RA Yamamoto Y., Koyama H., Kochian L.V.;
RT "AtALMT1, which encodes a malate transporter, is identified as one of
RT several genes critical for aluminum tolerance in Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:9738-9743(2006).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ACTIVITY REGULATION,
RP AND DISRUPTION PHENOTYPE.
RX PubMed=18005230; DOI=10.1111/j.1365-313x.2007.03367.x;
RA Kovermann P., Meyer S., Hoertensteiner S., Picco C., Scholz-Starke J.,
RA Ravera S., Lee Y., Martinoia E.;
RT "The Arabidopsis vacuolar malate channel is a member of the ALMT family.";
RL Plant J. 52:1169-1180(2007).
CC -!- FUNCTION: Vacuolar malate channel. Has a higher selectivity for malate
CC than for fumarate. Exhibits also a weak chloride conductance.
CC {ECO:0000269|PubMed:18005230}.
CC -!- ACTIVITY REGULATION: Slow activation by external aluminum.
CC {ECO:0000269|PubMed:18005230}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in hypocotyls, leaves, roots, flowers,
CC sepals and stamina. In leaves, expressed almost exclusively in
CC mesophyll cells. {ECO:0000269|PubMed:18005230}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC {ECO:0000269|PubMed:18005230}.
CC -!- SIMILARITY: Belongs to the aromatic acid exporter (TC 2.A.85) family.
CC {ECO:0000305}.
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DR EMBL; AB026658; BAB01110.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76098.1; -; Genomic_DNA.
DR EMBL; AY099663; AAM20514.1; -; mRNA.
DR EMBL; BT000258; AAN15577.1; -; mRNA.
DR RefSeq; NP_188473.1; NM_112729.4.
DR AlphaFoldDB; Q9LS46; -.
DR SMR; Q9LS46; -.
DR STRING; 3702.AT3G18440.1; -.
DR TCDB; 2.A.85.2.7; the aromatic acid exporter (arae) family.
DR iPTMnet; Q9LS46; -.
DR SwissPalm; Q9LS46; -.
DR PaxDb; Q9LS46; -.
DR PRIDE; Q9LS46; -.
DR ProteomicsDB; 244813; -.
DR EnsemblPlants; AT3G18440.1; AT3G18440.1; AT3G18440.
DR GeneID; 821373; -.
DR Gramene; AT3G18440.1; AT3G18440.1; AT3G18440.
DR KEGG; ath:AT3G18440; -.
DR Araport; AT3G18440; -.
DR TAIR; locus:2095067; AT3G18440.
DR eggNOG; KOG4711; Eukaryota.
DR HOGENOM; CLU_020841_1_2_1; -.
DR InParanoid; Q9LS46; -.
DR OMA; WEEVVII; -.
DR OrthoDB; 680186at2759; -.
DR PhylomeDB; Q9LS46; -.
DR PRO; PR:Q9LS46; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LS46; baseline and differential.
DR Genevisible; Q9LS46; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009705; C:plant-type vacuole membrane; IDA:TAIR.
DR GO; GO:0005253; F:anion channel activity; IDA:TAIR.
DR GO; GO:0015743; P:malate transport; IMP:TAIR.
DR InterPro; IPR020966; ALMT.
DR Pfam; PF11744; ALMT; 1.
PE 2: Evidence at transcript level;
KW Chloride; Ion channel; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Vacuole.
FT CHAIN 1..598
FT /note="Aluminum-activated malate transporter 9"
FT /id="PRO_0000401468"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 598 AA; 67046 MW; 5712DDEE9472A267 CRC64;
MAAKQGSFRH GILEKRERLL SNNGFSDFRF TDIESNDLLE NENCGRRTRL CCCCSCGNLS
EKISGVYDDA KDVARKAWEM GVSDPRKIVF SAKIGLALTI VALLIFYQEP NPDLSRYSVW
AILTVVVVFE FTIGATLSKG FNRALGTLSA GGLALGMAEL STLFGDWEEI FCTLSIFCIG
FLATFMKLYP SMKAYEYGFR VFLLTYCYIL ISGFRTGQFI EVAISRFLLI ALGAGVSLGV
NMFIYPIWAG EDLHNLVVKN FMNVATSLEG CVNGYLRCLE YERIPSKILT YQASEDPVYK
GYRSAVESTS QEESLMSFAI WEPPHGPYKS FNYPWKNYVK LSGALKHCAF TVMALHGCIL
SEIQAPEERR QVFRQELQRV GVEGAKLLRE LGEKVKKMEK LGPVDLLFEV HLAAEELQHK
IDKKSYLLVN SECWEIGNRA TKESEPQELL SLEDSDPPEN HAPPIYAFKS LSEAVLEIPP
SWGEKNHREA LNHRPTFSKQ VSWPARLVLP PHLETTNGAS PLVETTKTYE SASALSLATF
ASLLIEFVAR LQNVVDAFKE LSQKANFKEP EIVTTGTDVE FSGERVGLGQ KIRRCFGM
