ID   ALMT6_ARATH             Reviewed;         538 AA.
AC   Q9SHM1;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Aluminum-activated malate transporter 6;
DE            Short=AtALMT6;
GN   Name=ALMT6; OrderedLocusNames=At2g17470; ORFNames=F5J6.5, MJB20;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=16740662; DOI=10.1073/pnas.0602868103;
RA   Hoekenga O.A., Maron L.G., Pineros M.A., Cancado G.M., Shaff J.,
RA   Kobayashi Y., Ryan P.R., Dong B., Delhaize E., Sasaki T., Matsumoto H.,
RA   Yamamoto Y., Koyama H., Kochian L.V.;
RT   "AtALMT1, which encodes a malate transporter, is identified as one of
RT   several genes critical for aluminum tolerance in Arabidopsis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:9738-9743(2006).
CC   -!- FUNCTION: Malate transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the aromatic acid exporter (TC 2.A.85) family.
CC       {ECO:0000305}.
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DR   EMBL; AC007584; AAD32904.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC06632.1; -; Genomic_DNA.
DR   PIR; E84552; E84552.
DR   RefSeq; NP_179338.1; NM_127301.3.
DR   AlphaFoldDB; Q9SHM1; -.
DR   SMR; Q9SHM1; -.
DR   STRING; 3702.AT2G17470.1; -.
DR   PaxDb; Q9SHM1; -.
DR   PRIDE; Q9SHM1; -.
DR   ProteomicsDB; 244950; -.
DR   EnsemblPlants; AT2G17470.1; AT2G17470.1; AT2G17470.
DR   GeneID; 816253; -.
DR   Gramene; AT2G17470.1; AT2G17470.1; AT2G17470.
DR   KEGG; ath:AT2G17470; -.
DR   Araport; AT2G17470; -.
DR   TAIR; locus:2053878; AT2G17470.
DR   eggNOG; KOG4711; Eukaryota.
DR   HOGENOM; CLU_020841_1_2_1; -.
DR   InParanoid; Q9SHM1; -.
DR   PhylomeDB; Q9SHM1; -.
DR   PRO; PR:Q9SHM1; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q9SHM1; baseline and differential.
DR   Genevisible; Q9SHM1; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009705; C:plant-type vacuole membrane; IBA:GO_Central.
DR   GO; GO:0005774; C:vacuolar membrane; IDA:TAIR.
DR   GO; GO:0015140; F:malate transmembrane transporter activity; IDA:TAIR.
DR   GO; GO:0071423; P:malate transmembrane transport; IDA:TAIR.
DR   InterPro; IPR020966; ALMT.
DR   Pfam; PF11744; ALMT; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Ion channel; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..538
FT                   /note="Aluminum-activated malate transporter 6"
FT                   /id="PRO_0000401465"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   COILED          357..410
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   538 AA;  60696 MW;  8011E7377AD84447 CRC64;
     MGPFHQQSRE RLLSQNEYSD MCFRKITNLC ELGHSDRRRI FFAVKMGMAL ALCSVVIFLK
     EPLHDASKYS VWGILTVVVV FEYSVGATLV KGFNRAIGTV SAGGLALGIA RLSVLSRDFE
     QTIIITCIFL AGFIASYSKL HPAMKPYEYA FRVFLLTFCI VLVSGNNTGD FFSTAYYRFL
     FIVVGATTCL VVNIFIFPIW AGEDLHKLVA NNFKSVANSL EGCVNGYLQC VEYERVPSKI
     LTYQTSDDPL YSGYRSAIQS TNQEESLLDF AIWEPPHGPY RTFNHPWKNY VKLSGAVRHC
     AFTVMAIHGC ILSEIQAAPE KRQAFRHELQ RVGNEGAKVL RLIGEKVEKM ENLGPGEILN
     DVQRAAEELQ MKIDSKSYLL VNSESWAATK EKAEAEEYEE EAHETKVIKS LSQIWDTNSS
     SNNQNPASGN DESQIWESTE SMMLRNRETW PSVSFIGGSV VNETVYKVYE SASSLSLATF
     ASLLIEFVAR LENLVNAFEE LSTKADFRDP VPLNVVDQEG LWTTLMRLRR LRRYFGRS