ALMT4_ARATH
ID ALMT4_ARATH Reviewed; 548 AA.
AC Q9C6L8;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Aluminum-activated malate transporter 4;
DE Short=AtALMT4;
GN Name=ALMT4; OrderedLocusNames=At1g25480; ORFNames=F2J7.18;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16740662; DOI=10.1073/pnas.0602868103;
RA Hoekenga O.A., Maron L.G., Pineros M.A., Cancado G.M., Shaff J.,
RA Kobayashi Y., Ryan P.R., Dong B., Delhaize E., Sasaki T., Matsumoto H.,
RA Yamamoto Y., Koyama H., Kochian L.V.;
RT "AtALMT1, which encodes a malate transporter, is identified as one of
RT several genes critical for aluminum tolerance in Arabidopsis.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:9738-9743(2006).
CC -!- FUNCTION: Malate transporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the aromatic acid exporter (TC 2.A.85) family.
CC {ECO:0000305}.
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DR EMBL; AC079281; AAG50799.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE30631.1; -; Genomic_DNA.
DR PIR; A86385; A86385.
DR RefSeq; NP_173919.1; NM_102359.3.
DR AlphaFoldDB; Q9C6L8; -.
DR SMR; Q9C6L8; -.
DR STRING; 3702.AT1G25480.1; -.
DR PaxDb; Q9C6L8; -.
DR PRIDE; Q9C6L8; -.
DR ProteomicsDB; 244953; -.
DR EnsemblPlants; AT1G25480.1; AT1G25480.1; AT1G25480.
DR GeneID; 839134; -.
DR Gramene; AT1G25480.1; AT1G25480.1; AT1G25480.
DR KEGG; ath:AT1G25480; -.
DR Araport; AT1G25480; -.
DR TAIR; locus:2031160; AT1G25480.
DR eggNOG; KOG4711; Eukaryota.
DR HOGENOM; CLU_020841_1_2_1; -.
DR InParanoid; Q9C6L8; -.
DR OMA; AQQNYHE; -.
DR OrthoDB; 680186at2759; -.
DR PhylomeDB; Q9C6L8; -.
DR PRO; PR:Q9C6L8; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C6L8; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009705; C:plant-type vacuole membrane; IBA:GO_Central.
DR GO; GO:0005773; C:vacuole; IDA:TAIR.
DR GO; GO:0005253; F:anion channel activity; IDA:TAIR.
DR GO; GO:0071423; P:malate transmembrane transport; IDA:TAIR.
DR GO; GO:0090332; P:stomatal closure; IMP:TAIR.
DR InterPro; IPR020966; ALMT.
DR Pfam; PF11744; ALMT; 1.
PE 3: Inferred from homology;
KW Coiled coil; Ion channel; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..548
FT /note="Aluminum-activated malate transporter 4"
FT /id="PRO_0000401463"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT COILED 385..444
FT /evidence="ECO:0000255"
SQ SEQUENCE 548 AA; 61720 MW; ACB3B0F801D27518 CRC64;
MADQTREAFL SRKACSDFGF NDSNIIDDRR SKFRCFRFCS DGITASWKAL YDIGAKLYEM
GRSDRRKVYF SVKMGMALAL CSFVIYLKEP LRDASKYAVW AILTVVVVFE YSIGATLVKG
FNRAIGTLSA GGLALGIARL SVSAGEFEEL IIIISIFIAG FSASYLKLYP AMKSYEYAFR
VFLLTYCIVL VSGNNSRDFF STAYYRFLLI LVGAGICLGV NIFILPIWAG EDLHKLVVKN
FKSVANSLEG CVNGYLQCVE YERIPSKILT YQASDDPLYS GYRSVVQSTS QEDSLLDFAV
WEPPHGPYKT FHHPWANYVK LSGAVRHCAF MVMAMHGCIL SEIQAAPEKR QAFRQELQRV
GNEGAKVLRL FGEKVEKMEK LSPGNVLKDV QRAAEELQMK IDSNSFLLVN SESWAAMKEK
AEAEEAQQNY HEAKDDESKV IQSLSQIWDN NNNPHHQNQH AGNDSQLWIS TESMMLRNRE
NWPSVSFIGG SMINEIESKV YESASSLSLA TFASLLIEFV ARLQNIVNAY EELSTKADFK
EQVSETRI
