ID   ALMT2_ARATH             Reviewed;         501 AA.
AC   Q9SJE8;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 2.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Aluminum-activated malate transporter 2;
DE            Short=AtALMT2;
GN   Name=ALMT2; OrderedLocusNames=At1g08440; ORFNames=T27G7.12;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   INDUCTION BY ALUMINUM.
RX   PubMed=16488918; DOI=10.1093/jxb/erj080;
RA   Gabrielson K.M., Cancel J.D., Morua L.F., Larsen P.B.;
RT   "Identification of dominant mutations that confer increased aluminum
RT   tolerance through mutagenesis of the Al-sensitive Arabidopsis mutant, als3-
RT   1.";
RL   J. Exp. Bot. 57:943-951(2006).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=16740662; DOI=10.1073/pnas.0602868103;
RA   Hoekenga O.A., Maron L.G., Pineros M.A., Cancado G.M., Shaff J.,
RA   Kobayashi Y., Ryan P.R., Dong B., Delhaize E., Sasaki T., Matsumoto H.,
RA   Yamamoto Y., Koyama H., Kochian L.V.;
RT   "AtALMT1, which encodes a malate transporter, is identified as one of
RT   several genes critical for aluminum tolerance in Arabidopsis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:9738-9743(2006).
CC   -!- FUNCTION: Malate transporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Up-regulated by aluminum. {ECO:0000269|PubMed:16488918}.
CC   -!- SIMILARITY: Belongs to the aromatic acid exporter (TC 2.A.85) family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF22891.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC006932; AAF22891.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE28290.1; -; Genomic_DNA.
DR   PIR; F86217; F86217.
DR   RefSeq; NP_172320.1; NM_100717.2.
DR   AlphaFoldDB; Q9SJE8; -.
DR   SMR; Q9SJE8; -.
DR   STRING; 3702.AT1G08440.1; -.
DR   PaxDb; Q9SJE8; -.
DR   PRIDE; Q9SJE8; -.
DR   EnsemblPlants; AT1G08440.1; AT1G08440.1; AT1G08440.
DR   GeneID; 837364; -.
DR   Gramene; AT1G08440.1; AT1G08440.1; AT1G08440.
DR   KEGG; ath:AT1G08440; -.
DR   Araport; AT1G08440; -.
DR   TAIR; locus:2201791; AT1G08440.
DR   eggNOG; KOG4711; Eukaryota.
DR   HOGENOM; CLU_020841_2_2_1; -.
DR   InParanoid; Q9SJE8; -.
DR   OMA; FIRFFPQ; -.
DR   OrthoDB; 363404at2759; -.
DR   PhylomeDB; Q9SJE8; -.
DR   PRO; PR:Q9SJE8; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9SJE8; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009705; C:plant-type vacuole membrane; IBA:GO_Central.
DR   GO; GO:0034220; P:ion transmembrane transport; IEA:UniProt.
DR   GO; GO:0015743; P:malate transport; IEA:InterPro.
DR   InterPro; IPR020966; ALMT.
DR   Pfam; PF11744; ALMT; 1.
PE   2: Evidence at transcript level;
KW   Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..501
FT                   /note="Aluminum-activated malate transporter 2"
FT                   /id="PRO_0000401461"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          398..425
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   501 AA;  55682 MW;  C9CACE58901DB903 CRC64;
     MEKVREIVRE GRRVGKEDPR RVVHAFKVGL ALALVSSFYY YQPLYDNFGV NAMWAVMTVV
     VVFEFSVGAT LGKGLNRAVA TLVAGGLGIG AHHLASLSGP TVEPILLAIF VFVLAALSTF
     VRFFPRVKAR YDYGVLIFIL TFALISVSGF REDEILDLAH KRLSTVIMGG VSCVLISIFV
     CPVWAGQDLH SLLASNFDTL SHFLQEFGDE YFEATEDGDI KEVEKRRRNL ERYKSVLNSK
     SNEEALANFA KWEPRHGQFR FRHPWRQYLA VGALLRQSAY RIDALNSNIN SDMQIPMDIK
     KKIEEPLRRM SSESGKSMKE VSISLKNMTI SSSFDIHVVN SQSACKTLST LLKSGILNDV
     EPLQMISLMT TVSLLIDIVN LTEKISESVH ELASAAKFKN KKKPSKSNSG SIGQAMPNKS
     HDDDDHVVTI LGDVDTSNNV DQSQSHGEIS VDSCHHVTIK INDDDSIHDK NEDGDIHVHT
     NRVSCDHTNA SDLLDSGVKK N