ID   ALMA7_EMIHU             Reviewed;         341 AA.
AC   R1CW23;
DT   16-SEP-2015, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2013, sequence version 1.
DT   03-AUG-2022, entry version 26.
DE   RecName: Full=Dimethylsulfonioproprionate lyase 7 {ECO:0000305};
DE            Short=DMSP lyase 7 {ECO:0000305};
DE            EC=4.4.1.3 {ECO:0000250|UniProtKB:P0DN21};
DE   AltName: Full=Dimethylpropiothetin dethiomethylase 7 {ECO:0000305};
GN   Name=ALMA7 {ECO:0000303|PubMed:26113722};
GN   ORFNames=EMIHUDRAFT_114859 {ECO:0000312|EMBL:EOD26887.1};
OS   Emiliania huxleyi (Coccolithophore) (Pontosphaera huxleyi).
OC   Eukaryota; Haptista; Haptophyta; Prymnesiophyceae; Isochrysidales;
OC   Noelaerhabdaceae; Emiliania.
OX   NCBI_TaxID=2903;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCMP1516;
RX   PubMed=23760476; DOI=10.1038/nature12221;
RA   Read B.A., Kegel J., Klute M.J., Kuo A., Lefebvre S.C., Maumus F.,
RA   Mayer C., Miller J., Monier A., Salamov A., Young J., Aguilar M.,
RA   Claverie J.M., Frickenhaus S., Gonzalez K., Herman E.K., Lin Y.C.,
RA   Napier J., Ogata H., Sarno A.F., Shmutz J., Schroeder D., de Vargas C.,
RA   Verret F., von Dassow P., Valentin K., Van de Peer Y., Wheeler G.,
RA   Dacks J.B., Delwiche C.F., Dyhrman S.T., Glockner G., John U., Richards T.,
RA   Worden A.Z., Zhang X., Grigoriev I.V., Allen A.E., Bidle K., Borodovsky M.,
RA   Bowler C., Brownlee C., Cock J.M., Elias M., Gladyshev V.N., Groth M.,
RA   Guda C., Hadaegh A., Iglesias-Rodriguez M.D., Jenkins J., Jones B.M.,
RA   Lawson T., Leese F., Lindquist E., Lobanov A., Lomsadze A., Malik S.B.,
RA   Marsh M.E., Mackinder L., Mock T., Mueller-Roeber B., Pagarete A.,
RA   Parker M., Probert I., Quesneville H., Raines C., Rensing S.A.,
RA   Riano-Pachon D.M., Richier S., Rokitta S., Shiraiwa Y., Soanes D.M.,
RA   van der Giezen M., Wahlund T.M., Williams B., Wilson W., Wolfe G.,
RA   Wurch L.L.;
RT   "Pan genome of the phytoplankton Emiliania underpins its global
RT   distribution.";
RL   Nature 499:209-213(2013).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=26113722; DOI=10.1126/science.aab1586;
RA   Alcolombri U., Ben-Dor S., Feldmesser E., Levin Y., Tawfik D.S., Vardi A.;
RT   "Identification of the algal dimethyl sulfide-releasing enzyme: A missing
RT   link in the marine sulfur cycle.";
RL   Science 348:1466-1469(2015).
CC   -!- FUNCTION: Mediates cleavage of dimethylsulfonioproprionate (DMSP) into
CC       dimethyl sulfide (DMS) and acrylate. DMS is the principal form by which
CC       sulfur is transported from oceans to the atmosphere and is a key
CC       component of the ocean sulfur cycle. {ECO:0000250|UniProtKB:P0DN21}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S,S-dimethyl-beta-propiothetin = acrylate + dimethyl sulfide +
CC         H(+); Xref=Rhea:RHEA:19965, ChEBI:CHEBI:15378, ChEBI:CHEBI:16457,
CC         ChEBI:CHEBI:17437, ChEBI:CHEBI:37080; EC=4.4.1.3;
CC         Evidence={ECO:0000250|UniProtKB:P0DN21};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250|UniProtKB:P0DN21}.
CC   -!- SIMILARITY: Belongs to the aspartate/glutamate racemases family. ALMA1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; KB865129; EOD26887.1; -; Genomic_DNA.
DR   RefSeq; XP_005779316.1; XM_005779259.1.
DR   AlphaFoldDB; R1CW23; -.
DR   SMR; R1CW23; -.
DR   GeneID; 17272432; -.
DR   KEGG; ehx:EMIHUDRAFT_114859; -.
DR   eggNOG; ENOG502RZWQ; Eukaryota.
DR   HOGENOM; CLU_722474_0_0_1; -.
DR   Proteomes; UP000013827; Unassembled WGS sequence.
DR   GO; GO:0047869; F:dimethylpropiothetin dethiomethylase activity; IEA:UniProtKB-EC.
PE   3: Inferred from homology;
KW   Lyase; Reference proteome.
FT   CHAIN           1..341
FT                   /note="Dimethylsulfonioproprionate lyase 7"
FT                   /id="PRO_0000433894"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          319..341
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   341 AA;  37530 MW;  F28DD5CF87952654 CRC64;
     MAGKDRKTIE KNYPGAEVDE GGRFKPLPPA DDDAKLLVCE YPSLGVIRLD YDYPPALGDI
     DHPGSFYYDV FYRVVPGLTF GMCQKGEMPD EIKQRFIDAI KWLDAQGVAG ITSDCGFFMN
     FQDLARTVTD KPVFMSSLCQ LPAVVCAYAA HEHIALFTAN GESLKPMRDL IKKECGVDPE
     ESRFIIVGCQ DVPGFEAVAN GDRVDVDSVM PHIVRLAKET VAKYADTAKP IRAILFECTE
     LPPYSDAVRA ATRLPVFDAI TSCNSFLAAL MDNPRFGVNN WHLSWDGSQT DYRYGDNLSA
     DLKAKLVNAE HAENVAAAER KLAKDRQKPK PATGTGTAFD A