ALLT_SPOFR
ID ALLT_SPOFR Reviewed; 182 AA.
AC Q70XC3; Q7Z1L4; Q8IFJ7;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 2.
DT 25-MAY-2022, entry version 35.
DE RecName: Full=Allatotropin;
DE Short=AT;
DE Short=Spofr-AT;
DE Flags: Precursor;
OS Spodoptera frugiperda (Fall armyworm).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Amphipyrinae; Spodoptera.
OX NCBI_TaxID=7108;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAD48083.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), AND DEVELOPMENTAL STAGE.
RC TISSUE=Brain {ECO:0000269|PubMed:12706626};
RX PubMed=12706626; DOI=10.1016/s0965-1748(03)00005-5;
RA Abdel-latief M., Meyering-Vos M., Hoffmann K.H.;
RT "Molecular characterisation of cDNAs from the fall armyworm Spodoptera
RT frugiperda encoding Manduca sexta allatotropin and allatostatin
RT preprohormone peptides.";
RL Insect Biochem. Mol. Biol. 33:467-476(2003).
CC -!- FUNCTION: Neuropeptide stimulator of juvenile hormone synthesis.
CC {ECO:0000250|UniProtKB:P21786}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1 {ECO:0000269|PubMed:12706626};
CC IsoId=Q70XC3-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:12706626};
CC IsoId=Q70XC3-2; Sequence=VSP_027582, VSP_027583;
CC Name=3 {ECO:0000269|PubMed:12706626};
CC IsoId=Q70XC3-3; Sequence=VSP_027583;
CC -!- DEVELOPMENTAL STAGE: Highest level in brain of sixth larval stage.
CC Similar levels in adult male brain. Lower levels in adult female and
CC early pupal brain. Lowest levels in prepupal and 10 day old pupal
CC brain. {ECO:0000269|PubMed:12706626}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAD48594.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AJ488180; CAD32495.1; -; mRNA.
DR EMBL; AJ508061; CAD48083.1; -; mRNA.
DR EMBL; AJ508907; CAD48594.1; ALT_FRAME; mRNA.
DR AlphaFoldDB; Q70XC3; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW Neuropeptide; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..37
FT /evidence="ECO:0000250|UniProtKB:P21786, ECO:0000255"
FT /id="PRO_0000020688"
FT PEPTIDE 39..51
FT /note="Allatotropin"
FT /evidence="ECO:0000250|UniProtKB:P21786"
FT /id="PRO_0000020689"
FT PROPEP 55..182
FT /evidence="ECO:0000250"
FT /id="PRO_0000020690"
FT REGION 51..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 51
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000250"
FT VAR_SEQ 63..100
FT /note="HQDSYDSHARRKFNPKSNLMVAYDFGKRSGNDDVTDEV -> L (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:12706626"
FT /id="VSP_027582"
FT VAR_SEQ 158..173
FT /note="HSFGLVRERDAEQSRF -> DGMLSSEELLRNVV (in isoform 2 and
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:12706626"
FT /id="VSP_027583"
SQ SEQUENCE 182 AA; 20860 MW; 883FA595C9FF5B6D CRC64;
MNISMHLAVA VAAAACLCVC AAAPENRLAR TKQQRPTRGF KNVEMMTARG FGKRDRPHTR
AEHQDSYDSH ARRKFNPKSN LMVAYDFGKR SGNDDVTDEV YGLDNFWEML EATPEREGQE
NDEKTLESIP LDWFVNEMLN NPDFARSVVR KFIDLNQHSF GLVRERDAEQ SRFRAICGPQ
VH
