ALKL1_MOUSE
ID ALKL1_MOUSE Reviewed; 127 AA.
AC J3QPP8;
DT 10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 1.
DT 03-AUG-2022, entry version 48.
DE RecName: Full=ALK and LTK ligand 1 {ECO:0000250|UniProtKB:Q6UXT8};
DE AltName: Full=Augmentor beta {ECO:0000250|UniProtKB:Q6UXT8};
DE Short=AUG-beta {ECO:0000250|UniProtKB:Q6UXT8};
DE Flags: Precursor;
GN Name=Alkal1 {ECO:0000312|MGI:MGI:3645495};
GN Synonyms=Fam150a {ECO:0000312|MGI:MGI:3645495};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Cytokine that acts as a physiological ligand for receptor
CC tyrosine kinase LTK, leading to its activation. Monomeric ALKAL1 binds
CC to LTK, leading to LTK homodimerization and activation. In contrast to
CC ALKAL2, does not act as a potent physiological ligand for ALK.
CC {ECO:0000250|UniProtKB:Q6UXT8}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6UX46}. Cell
CC membrane {ECO:0000250|UniProtKB:Q6UXT8}. Note=Following interaction
CC with receptor tyrosine kinase LTK, associates with the cell membrane,
CC membrane-binding is required to activate LTK.
CC {ECO:0000250|UniProtKB:Q6UX46}.
CC -!- SIMILARITY: Belongs to the ALKAL family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC139064; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS56620.1; -.
DR RefSeq; NP_001182661.1; NM_001195732.1.
DR AlphaFoldDB; J3QPP8; -.
DR SMR; J3QPP8; -.
DR STRING; 10090.ENSMUSP00000137420; -.
DR PhosphoSitePlus; J3QPP8; -.
DR PaxDb; J3QPP8; -.
DR PRIDE; J3QPP8; -.
DR Antibodypedia; 24431; 23 antibodies from 8 providers.
DR Ensembl; ENSMUST00000133144; ENSMUSP00000137420; ENSMUSG00000087247.
DR GeneID; 620393; -.
DR KEGG; mmu:620393; -.
DR UCSC; uc007afv.2; mouse.
DR CTD; 389658; -.
DR MGI; MGI:3645495; Alkal1.
DR VEuPathDB; HostDB:ENSMUSG00000087247; -.
DR eggNOG; ENOG502RZG1; Eukaryota.
DR GeneTree; ENSGT00940000159969; -.
DR HOGENOM; CLU_126080_0_0_1; -.
DR InParanoid; J3QPP8; -.
DR OMA; MRAVSEW; -.
DR OrthoDB; 1432187at2759; -.
DR PhylomeDB; J3QPP8; -.
DR TreeFam; TF333390; -.
DR BioGRID-ORCS; 620393; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Alkal1; mouse.
DR PRO; PR:J3QPP8; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; J3QPP8; protein.
DR Bgee; ENSMUSG00000087247; Expressed in lung and 4 other tissues.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005125; F:cytokine activity; ISS:UniProtKB.
DR GO; GO:0030298; F:receptor signaling protein tyrosine kinase activator activity; ISS:UniProtKB.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; ISO:MGI.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:MGI.
DR GO; GO:0070378; P:positive regulation of ERK5 cascade; ISO:MGI.
DR GO; GO:0010976; P:positive regulation of neuron projection development; ISO:MGI.
DR InterPro; IPR029364; FAM150A/B.
DR PANTHER; PTHR28676; PTHR28676; 1.
DR Pfam; PF15129; FAM150; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cytokine; Disulfide bond; Membrane; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..127
FT /note="ALK and LTK ligand 1"
FT /evidence="ECO:0000255"
FT /id="PRO_5003776676"
FT DISULFID 88..124
FT /evidence="ECO:0000250|UniProtKB:Q6UXT8"
FT DISULFID 102..111
FT /evidence="ECO:0000250|UniProtKB:Q6UXT8"
SQ SEQUENCE 127 AA; 14246 MW; 9F259C119553C074 CRC64;
MWLTKPSTPV SALLLLALAL SPPGTQGRPQ RSLAARVAEL RPELFLPVTG TRLPPRASRS
TEIFPRDLTL KDKFIKHFTG PVTFSAECSK HFHRLYHNTR DCSTPAYYKR CARLLTRLAV
SPLCSQT
