GALU_PSEAE
ID GALU_PSEAE Reviewed; 279 AA.
AC Q9I291;
DT 04-MAY-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=UTP--glucose-1-phosphate uridylyltransferase;
DE EC=2.7.7.9;
DE AltName: Full=Alpha-D-glucosyl-1-phosphate uridylyltransferase;
DE AltName: Full=UDP-glucose pyrophosphorylase;
DE Short=UDPGP;
DE AltName: Full=Uridine diphosphoglucose pyrophosphorylase;
GN Name=galU; OrderedLocusNames=PA2023;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: May play a role in stationary phase survival. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-
CC alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601,
CC ChEBI:CHEBI:58885; EC=2.7.7.9;
CC -!- SIMILARITY: Belongs to the UDPGP type 2 family. {ECO:0000305}.
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DR EMBL; AE004091; AAG05411.1; -; Genomic_DNA.
DR PIR; A83394; A83394.
DR RefSeq; NP_250713.1; NC_002516.2.
DR RefSeq; WP_003088639.1; NZ_QZGE01000026.1.
DR AlphaFoldDB; Q9I291; -.
DR SMR; Q9I291; -.
DR STRING; 287.DR97_5824; -.
DR PaxDb; Q9I291; -.
DR PRIDE; Q9I291; -.
DR DNASU; 879968; -.
DR EnsemblBacteria; AAG05411; AAG05411; PA2023.
DR GeneID; 879968; -.
DR KEGG; pae:PA2023; -.
DR PATRIC; fig|208964.12.peg.2108; -.
DR PseudoCAP; PA2023; -.
DR HOGENOM; CLU_029499_1_2_6; -.
DR InParanoid; Q9I291; -.
DR OMA; MHYVRQG; -.
DR PhylomeDB; Q9I291; -.
DR BioCyc; PAER208964:G1FZ6-2061-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009244; P:lipopolysaccharide core region biosynthetic process; IMP:PseudoCAP.
DR GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR CDD; cd02541; UGPase_prokaryotic; 1.
DR Gene3D; 3.90.550.10; -; 1.
DR InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR43197; PTHR43197; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; SSF53448; 1.
DR TIGRFAMs; TIGR01099; galU; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase; Reference proteome; Transferase.
FT CHAIN 1..279
FT /note="UTP--glucose-1-phosphate uridylyltransferase"
FT /id="PRO_0000201361"
SQ SEQUENCE 279 AA; 31236 MW; 889B6B8639F159B2 CRC64;
MIKKCLFPAA GYGTRFLPAT KAMPKEMLPV VNKPLIQYAV EEALEAGLSE IGIVTGRGKR
SLEDHFDISY ELEHQIRNTD KEKYLVGIRR LIDECTFAYT RQVEMKGLGH AILTGRPLIG
DEPFAVVLAD DLCLNLEGDS VLKQMVKLYN QFRCSIVAIQ EVPPEETNKY GVIAGEMIRD
DIFRVNTMVE KPKPEEAPSN LAIIGRYILT PDIFDLIEQT EPGKGGEIQI TDALMKQAQD
GCVLAYKFKG KRFDCGSAEG YIEATNFCYE NLYKTGKAH
