ID   ALG13_RAT               Reviewed;         165 AA.
AC   Q5I0K7;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=UDP-N-acetylglucosamine transferase subunit ALG13 homolog;
DE            EC=2.4.1.141;
DE   AltName: Full=Glycosyltransferase 28 domain-containing protein 1;
GN   Name=Alg13; Synonyms=Glt28d1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PROTEIN SEQUENCE OF 153-159, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=Sprague-Dawley; TISSUE=Brain;
RA   Lubec G., Kang S.U.;
RL   Submitted (JUL-2007) to UniProtKB.
CC   -!- FUNCTION: May be involved in protein N-glycosylation, second step of
CC       the dolichol-linked oligosaccharide pathway. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-acetyl-alpha-D-glucosaminyl-diphosphodolichol + UDP-N-
CC         acetyl-alpha-D-glucosamine = H(+) + N,N'-diacetylchitobiosyl
CC         diphosphodolichol + UDP; Xref=Rhea:RHEA:23380, Rhea:RHEA-COMP:9519,
CC         Rhea:RHEA-COMP:9520, ChEBI:CHEBI:15378, ChEBI:CHEBI:57269,
CC         ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:58427;
CC         EC=2.4.1.141;
CC   -!- SUBUNIT: May interact with ALG14. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}. Note=Could
CC       be recruited to the cytosolic face of the endoplasmic reticulum
CC       membrane through its interaction with ALG14. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 28 family.
CC       {ECO:0000305}.
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DR   EMBL; BC088233; AAH88233.1; -; mRNA.
DR   RefSeq; NP_001013973.1; NM_001013951.1.
DR   AlphaFoldDB; Q5I0K7; -.
DR   SMR; Q5I0K7; -.
DR   STRING; 10116.ENSRNOP00000068463; -.
DR   PaxDb; Q5I0K7; -.
DR   PRIDE; Q5I0K7; -.
DR   ABCD; Q5I0K7; 1 sequenced antibody.
DR   Ensembl; ENSRNOT00000076680; ENSRNOP00000068463; ENSRNOG00000065758.
DR   GeneID; 300284; -.
DR   KEGG; rno:300284; -.
DR   CTD; 79868; -.
DR   RGD; 1359416; Alg13.
DR   eggNOG; KOG3349; Eukaryota.
DR   GeneTree; ENSGT00510000047493; -.
DR   InParanoid; Q5I0K7; -.
DR   OMA; NYLYYCK; -.
DR   OrthoDB; 1575485at2759; -.
DR   PhylomeDB; Q5I0K7; -.
DR   TreeFam; TF313788; -.
DR   PRO; PR:Q5I0K7; -.
DR   Proteomes; UP000002494; Chromosome X.
DR   Bgee; ENSRNOG00000005753; Expressed in pancreas and 19 other tissues.
DR   ExpressionAtlas; Q5I0K7; baseline and differential.
DR   Genevisible; Q5I0K7; RN.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0004577; F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006488; P:dolichol-linked oligosaccharide biosynthetic process; IEA:InterPro.
DR   GO; GO:1901215; P:negative regulation of neuron death; ISO:RGD.
DR   GO; GO:1904262; P:negative regulation of TORC1 signaling; ISO:RGD.
DR   GO; GO:0048167; P:regulation of synaptic plasticity; ISO:RGD.
DR   InterPro; IPR039042; Alg13-like.
DR   InterPro; IPR007235; Glyco_trans_28_C.
DR   PANTHER; PTHR12867; PTHR12867; 1.
DR   Pfam; PF04101; Glyco_tran_28_C; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Endoplasmic reticulum; Glycosyltransferase;
KW   Reference proteome; Transferase.
FT   CHAIN           1..165
FT                   /note="UDP-N-acetylglucosamine transferase subunit ALG13
FT                   homolog"
FT                   /id="PRO_0000254575"
SQ   SEQUENCE   165 AA;  18329 MW;  2BBFA7D967588B15 CRC64;
     MKRAFVTVGT TSFDDLVARV VANDTVQILK SLGYNHLVLQ IGRGTVVPEP FSTEPFTLDV
     YRYKESLKED LQQADLVISH AGAGSCLESL EKGKPLVVVV NEKLMNNHQF ELAKQLHKEG
     HLFYCTCSML PGLLQSMDLS TLKCYPPGQP EKFSAFLDKV VGLQK