ID   ALG11_XENTR             Reviewed;         487 AA.
AC   Q6P312;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase;
DE            EC=2.4.1.131;
DE   AltName: Full=Asparagine-linked glycosylation protein 11 homolog;
DE   AltName: Full=Glycolipid 2-alpha-mannosyltransferase;
GN   Name=alg11;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-
CC         beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-
CC         D-mannose = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-
CC         [alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-
CC         GlcNAc-diphosphodolichol + 2 GDP + 2 H(+); Xref=Rhea:RHEA:29523,
CC         Rhea:RHEA-COMP:12626, Rhea:RHEA-COMP:12627, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57527, ChEBI:CHEBI:58189, ChEBI:CHEBI:132511,
CC         ChEBI:CHEBI:132515; EC=2.4.1.131;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase group 1 family.
CC       Glycosyltransferase 4 subfamily. {ECO:0000305}.
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DR   EMBL; BC064222; AAH64222.1; -; mRNA.
DR   RefSeq; NP_989283.1; NM_203952.1.
DR   AlphaFoldDB; Q6P312; -.
DR   SMR; Q6P312; -.
DR   STRING; 8364.ENSXETP00000044752; -.
DR   CAZy; GT4; Glycosyltransferase Family 4.
DR   PaxDb; Q6P312; -.
DR   DNASU; 394898; -.
DR   Ensembl; ENSXETT00000044752; ENSXETP00000044752; ENSXETG00000020712.
DR   GeneID; 394898; -.
DR   KEGG; xtr:394898; -.
DR   CTD; 440138; -.
DR   Xenbase; XB-GENE-5934131; alg11.
DR   eggNOG; KOG1387; Eukaryota.
DR   HOGENOM; CLU_017896_2_0_1; -.
DR   InParanoid; Q6P312; -.
DR   OMA; WKHFTLI; -.
DR   OrthoDB; 1051021at2759; -.
DR   PhylomeDB; Q6P312; -.
DR   TreeFam; TF313056; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000020712; Expressed in egg cell and 13 other tissues.
DR   ExpressionAtlas; Q6P312; baseline and differential.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0004377; F:GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0006490; P:oligosaccharide-lipid intermediate biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006487; P:protein N-linked glycosylation; IBA:GO_Central.
DR   CDD; cd03806; GT4_ALG11-like; 1.
DR   InterPro; IPR038013; ALG11.
DR   InterPro; IPR031814; ALG11_N.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   PANTHER; PTHR45919; PTHR45919; 1.
DR   Pfam; PF15924; ALG11_N; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
PE   2: Evidence at transcript level;
KW   Glycosyltransferase; Membrane; Reference proteome; Transferase;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..487
FT                   /note="GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-
FT                   mannosyltransferase"
FT                   /id="PRO_0000295621"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   487 AA;  54815 MW;  50102122875412B0 CRC64;
     MAGILCLCGM MRLLTALFIP VLIASIGLCL VLVLLFICTR LWIQRKKKQS VEIGKDGKKK
     RVVAFFHPYC NAGGGGERVL WCALRSLQKR YKDAIYVIYT GDKDVSEEQI LNGAAARFNI
     KLSHPVKFIF LEKRGLVEAS FYPRFTLLGQ SLGSVVLGWE ALTKCVPDIY IDSMGYAFTL
     PLFKYVGGCQ VGCYVHYPTI SMDMLSVVRS QNARFNNAAF ISNNPVLSRL KLIYYYLFAV
     IYGWVGSCSD VIMVNSTWTF AHILDLWKCS ERTSIVYPPC DVQTFLDINL NQHKDIEEHS
     IVSIGQFRPE KDHPLQICAF AALLKKKTTE KLKLKLILIG GCRNNEDELR VSELKKLSSE
     LGIPVEFKVN IPFAELKKHL SEATIGLHTM WNEHFGIGIV ECMAAGTIIL AHNSGGPKLD
     IVVPYEEHET GFLADSVESY AAAMDYILCL TPEQRLTIRQ NARRSVARFS DQEFEANFLA
     SSEPLFM