ID   ALG11_DANRE             Reviewed;         500 AA.
AC   Q7ZW24;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase;
DE            EC=2.4.1.131;
DE   AltName: Full=Asparagine-linked glycosylation protein 11 homolog;
DE   AltName: Full=Glycolipid 2-alpha-mannosyltransferase;
GN   Name=alg11;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-
CC         beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-
CC         D-mannose = alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-
CC         [alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-
CC         GlcNAc-diphosphodolichol + 2 GDP + 2 H(+); Xref=Rhea:RHEA:29523,
CC         Rhea:RHEA-COMP:12626, Rhea:RHEA-COMP:12627, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57527, ChEBI:CHEBI:58189, ChEBI:CHEBI:132511,
CC         ChEBI:CHEBI:132515; EC=2.4.1.131;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase group 1 family.
CC       Glycosyltransferase 4 subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH45321.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC045321; AAH45321.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q7ZW24; -.
DR   SMR; Q7ZW24; -.
DR   STRING; 7955.ENSDARP00000049513; -.
DR   CAZy; GT4; Glycosyltransferase Family 4.
DR   PaxDb; Q7ZW24; -.
DR   ZFIN; ZDB-GENE-030131-7282; alg11.
DR   eggNOG; KOG1387; Eukaryota.
DR   InParanoid; Q7ZW24; -.
DR   PhylomeDB; Q7ZW24; -.
DR   PRO; PR:Q7ZW24; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0004377; F:GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0006490; P:oligosaccharide-lipid intermediate biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006487; P:protein N-linked glycosylation; IBA:GO_Central.
DR   CDD; cd03806; GT4_ALG11-like; 1.
DR   InterPro; IPR038013; ALG11.
DR   InterPro; IPR031814; ALG11_N.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   PANTHER; PTHR45919; PTHR45919; 1.
DR   Pfam; PF15924; ALG11_N; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
PE   2: Evidence at transcript level;
KW   Glycosyltransferase; Membrane; Reference proteome; Transferase;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..500
FT                   /note="GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-
FT                   mannosyltransferase"
FT                   /id="PRO_0000295619"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   500 AA;  56623 MW;  CF3A77A19CE21836 CRC64;
     MSAHDHFSLC LCDLIRLLWS LMLPCFYLSF LLTTILFLFI MGVRSWLQMK RKTRRVQDGR
     PAVAFFHPYC NAGGGGERVL WCALRALQNR YQDVSFVVYT GDQGVTAEEI LDGARRRFNI
     RLPRPVKFVF LKHRLLVEAK LYPHFTLLGQ SVGSIFLGWE ALTEFVPDLY IDSMGFAFTL
     PVFRYLGGCQ VGSYVHYPTI STDMLSVVRE RNPRFNNADY ISSNPVLSAI KVIYYCVFAL
     LYGLAGSCSD VIMVNSTWTL GHILALWRTP NRTSVVYPPC DVQAFLDVPI GEDNEEKEQK
     KCHSLVSVGQ FRPEKDHQLQ IRAFKKLLDR KEAEPAGREA VKLVLIGGCR NQEDEDRVLM
     LRGLCQELGI ADRVEFKLNI PFQELKKDLT DATIGLHTMW NEHFGIGIVE CMAAGTIILA
     HKSGGPKLDI VVPYDGGPTG FLADDEDNYA DAMERILSMS PATRLEMRRR ARLSVSRFSD
     QEFEGSFLSA MEPLMSTLRA