FUM21_GIBM7
ID FUM21_GIBM7 Reviewed; 672 AA.
AC W7LKW1; A5PEW1;
DT 30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 33.
DE RecName: Full=Fumonisin cluster-specific transcription factor FUM21 {ECO:0000305};
GN Name=FUM21; ORFNames=FVEG_14633;
OS Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot
OS fungus) (Fusarium verticillioides).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=334819;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=M3125 / FGSC 7600;
RX PubMed=12620260; DOI=10.1016/s1087-1845(02)00525-x;
RA Proctor R.H., Brown D.W., Plattner R.D., Desjardins A.E.;
RT "Co-expression of 15 contiguous genes delineates a fumonisin biosynthetic
RT gene cluster in Gibberella moniliformis.";
RL Fungal Genet. Biol. 38:237-249(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M3125 / FGSC 7600;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=M3125 / FGSC 7600;
RX PubMed=17483290; DOI=10.1128/ec.00400-06;
RA Brown D.W., Butchko R.A., Busman M., Proctor R.H.;
RT "The Fusarium verticillioides FUM gene cluster encodes a Zn(II)2Cys6
RT protein that affects FUM gene expression and fumonisin production.";
RL Eukaryot. Cell 6:1210-1218(2007).
RN [4]
RP INDUCTION.
RX PubMed=19382792; DOI=10.1021/jf900783u;
RA Myung K., Li S., Butchko R.A., Busman M., Proctor R.H., Abbas H.K.,
RA Calvo A.M.;
RT "FvVE1 regulates biosynthesis of the mycotoxins fumonisins and fusarins in
RT Fusarium verticillioides.";
RL J. Agric. Food Chem. 57:5089-5094(2009).
RN [5]
RP INDUCTION.
RX PubMed=22117026; DOI=10.1128/ec.05159-11;
RA Visentin I., Montis V., Doell K., Alabouvette C., Tamietti G.,
RA Karlovsky P., Cardinale F.;
RT "Transcription of genes in the biosynthetic pathway for fumonisin
RT mycotoxins is epigenetically and differentially regulated in the fungal
RT maize pathogen Fusarium verticillioides.";
RL Eukaryot. Cell 11:252-259(2012).
RN [6]
RP INDUCTION.
RX PubMed=22713715; DOI=10.1016/j.fgb.2012.06.003;
RA Butchko R.A., Brown D.W., Busman M., Tudzynski B., Wiemann P.;
RT "Lae1 regulates expression of multiple secondary metabolite gene clusters
RT in Fusarium verticillioides.";
RL Fungal Genet. Biol. 49:602-612(2012).
CC -!- FUNCTION: Transcription factor that regulates the expression the gene
CC cluster that mediates the biosynthesis of fumonisins B1 (FB1), B2
CC (FB2), B3 (FB3), and B4 (FB4), which are carcinogenic mycotoxins
CC (PubMed:17483290). {ECO:0000269|PubMed:17483290}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC -!- INDUCTION: Expression is controlled by the global regulators for
CC secondary metabolite VE1 and LAE1 (PubMed:19382792, PubMed:22713715).
CC Expression is increased under histone deacetylase (HDAC)-inhibiting
CC conditions (PubMed:22117026). {ECO:0000269|PubMed:19382792,
CC ECO:0000269|PubMed:22117026, ECO:0000269|PubMed:22713715}.
CC -!- DISRUPTION PHENOTYPE: Impairs the production of fumonisins
CC (PubMed:17483290). {ECO:0000269|PubMed:17483290}.
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DR EMBL; AF155773; ABQ95367.1; -; Genomic_DNA.
DR EMBL; DS022242; EWG36180.1; -; Genomic_DNA.
DR RefSeq; XP_018742371.1; XM_018903566.1.
DR AlphaFoldDB; W7LKW1; -.
DR GeneID; 30071509; -.
DR VEuPathDB; FungiDB:FVEG_14633; -.
DR Proteomes; UP000009096; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:1900685; P:positive regulation of fumonisin biosynthetic process; IDA:GO_Central.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..672
FT /note="Fumonisin cluster-specific transcription factor
FT FUM21"
FT /id="PRO_0000441153"
FT DNA_BIND 30..56
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 65..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 672 AA; 74101 MW; F5112C3E8C1D058C CRC64;
MAGSIVFVTD NQISANSRHK PRFRRRRGAC ESCKRRKVRC NGTNPCNQCQ KSSIECLYSS
SSWKANDGDT ERGPSGSPVQ HTRGSLTPPQ TSPYGGMACN GSAEESSRFD GSDAHSLLMS
LSNTDCTTNT EATEMSQWQN WFVSDLPLGS DVQLTGTSDE SLTDWLDPQL VNPADTAAIM
QTLSGEDLFK SSGPSYGMSE PPSRDSDPGF NTARNEQIAG FIQKLRSQRP FVLRDENPEA
PPGNIRGFYD AKFISQCFDA CDADPEGVRV LLERKSMDLI ADEITKYALA VDTETSVLFH
SLMAIGCHSL NLDQGHRAIG KGKYPASKFF KEALNARQHL RDSPSLGGLQ AILTMAYFSA
RVGDDSTSSF LADAAFCVQT LQLHNAGAIE QKYNSFLEQQ VAKRALWFLY SLEKPRCLAQ
GLLPLIHDDF VDYDPPPSAN YSTSEVDWFA INARFARICS SIIKERLGCK LGRTPSRRGK
DRASEYSASS VIKRLESLLE EWRDDLPFAG DFDATRSDEF AASTCAERRH RIKCLNKYWS
AIIATHSGQA RGVAEDGGAG VRLSRARCID AAQAILQNSH YVTSTDILSD ISLYYYITVA
TRVIMTVVIR DRFASDITGD PVQKNTATRK RETTHGRSIM SYVGIAIGLF SRLSLDIDVP
VDEVTELGKL GR
