FUJ4_GIBF5
ID FUJ4_GIBF5 Reviewed; 465 AA.
AC S0ECK8;
DT 25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT 18-SEP-2013, sequence version 1.
DT 25-MAY-2022, entry version 27.
DE RecName: Full=Fujikurins efflux protein FFUJ_12242 {ECO:0000305};
GN ORFNames=FFUJ_12242;
OS Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae
OS and foot rot disease fungus) (Fusarium fujikuroi).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=1279085;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], IDENTIFICATION, FUNCTION,
RP AND INDUCTION.
RC STRAIN=CBS 195.34 / IMI 58289 / NRRL A-6831;
RX PubMed=23825955; DOI=10.1371/journal.ppat.1003475;
RA Wiemann P., Sieber C.M.K., von Bargen K.W., Studt L., Niehaus E.-M.,
RA Espino J.J., Huss K., Michielse C.B., Albermann S., Wagner D.,
RA Bergner S.V., Connolly L.R., Fischer A., Reuter G., Kleigrewe K., Bald T.,
RA Wingfield B.D., Ophir R., Freeman S., Hippler M., Smith K.M., Brown D.W.,
RA Proctor R.H., Muensterkoetter M., Freitag M., Humpf H.-U., Gueldener U.,
RA Tudzynski B.;
RT "Deciphering the cryptic genome: genome-wide analyses of the rice pathogen
RT Fusarium fujikuroi reveal complex regulation of secondary metabolism and
RT novel metabolites.";
RL PLoS Pathog. 9:E1003475-E1003475(2013).
RN [2]
RP FUNCTION.
RX PubMed=26192387; DOI=10.1021/np5008137;
RA von Bargen K.W., Niehaus E.M., Krug I., Bergander K., Wuerthwein E.U.,
RA Tudzynski B., Humpf H.U.;
RT "Isolation and structure elucidation of fujikurins A-D: products of the
RT PKS19 gene cluster in Fusarium fujikuroi.";
RL J. Nat. Prod. 78:1809-1815(2015).
CC -!- FUNCTION: Efflux pump that may be involved in the secretion of
CC fujikurins (PubMed:23825955, PubMed:26192387).
CC {ECO:0000305|PubMed:23825955, ECO:0000305|PubMed:26192387}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- INDUCTION: The fujikurins gene cluster is specifically expressed during
CC rice infection (PubMed:23825955). {ECO:0000269|PubMed:23825955}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Monocarboxylate porter (TC 2.A.1.13) family. {ECO:0000305}.
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DR EMBL; HF679030; CCT72380.1; -; Genomic_DNA.
DR AlphaFoldDB; S0ECK8; -.
DR SMR; S0ECK8; -.
DR EnsemblFungi; CCT72380; CCT72380; FFUJ_12242.
DR VEuPathDB; FungiDB:FFUJ_12242; -.
DR HOGENOM; CLU_001265_1_0_1; -.
DR Proteomes; UP000016800; Chromosome 8.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..465
FT /note="Fujikurins efflux protein FFUJ_12242"
FT /id="PRO_0000442010"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 404..424
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 430..450
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 310
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 465 AA; 49779 MW; E7B6CB01B289D48B CRC64;
MATNVGGAVD NSRRSISDNR HDPEKPAELP DTLSGSETER PQDANPEAAL DQQASDAAKA
HDEGPPDGGT AAWMVVLGAW CCSFCSPGWI NSMGSFQEYY QREPLKDYSS SEIAWIPSLE
IFFLFGLGPI VGIIFDRYGP RPLIIGGTIF HVFGLMMASL AKTYYQFLLS QGVCSAIGVA
CLYSPALACI STWFLKRRGA AMGIMATGSS VGGVIFPIMI TRMIERNGYP WALRTAAFLI
LGLQVIACLT VRPRQKPVPK KLPAGRLAAP FTEPAFALLL AGIFILTYGM YIPIDYLPLS
GLQEAHMSVN MSQYLVAIMN AASLFGRLGA GYGADIIGRW NMFIIACGVT GISNLAVWIP
ATKSSITIGY AIMFGFASGA FVSLVGALPV SVSPIPELGY RMGIVFLVIS IPALTMAPIG
GAILQHASNG WVSLKVFAGV MCLVGSAIIL GSRMLYTEKR LIKAF
