ID   FUD1B_XENLA             Reviewed;         188 AA.
AC   Q6DFJ3;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=FUN14 domain-containing protein 1B;
GN   Name=fundc1-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as an activator of hypoxia-induced mitophagy, an
CC       important mechanism for mitochondrial quality control. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FUN14 family. {ECO:0000305}.
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DR   EMBL; BC076744; AAH76744.1; -; mRNA.
DR   RefSeq; NP_001086519.1; NM_001093050.1.
DR   AlphaFoldDB; Q6DFJ3; -.
DR   DNASU; 446354; -.
DR   GeneID; 446354; -.
DR   KEGG; xla:446354; -.
DR   CTD; 446354; -.
DR   OrthoDB; 1431148at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 446354; Expressed in muscle tissue and 19 other tissues.
DR   GO; GO:0031307; C:integral component of mitochondrial outer membrane; ISS:UniProtKB.
DR   GO; GO:0000422; P:autophagy of mitochondrion; ISS:UniProtKB.
DR   GO; GO:0001666; P:response to hypoxia; ISS:UniProtKB.
DR   InterPro; IPR007014; FUN14.
DR   PANTHER; PTHR21346; PTHR21346; 1.
DR   Pfam; PF04930; FUN14; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..188
FT                   /note="FUN14 domain-containing protein 1B"
FT                   /id="PRO_0000416277"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           52..55
FT                   /note="YXXL"
SQ   SEQUENCE   188 AA;  21035 MW;  A1327211725FF5BB CRC64;
     MSKKSTNIFT CSGAQHKWIQ VVNIDGNIFS IYVCFFVCFF FYLEPSSDDE SYEVLDLTEY
     ARRHHWWNRL FGRNSGPLTE KYSVATQIVI GGVSGWCAGF LFQKVGKLAA TAVGGGFLLL
     QIASHGGYIQ IDWKRVEKDV NKAKRKIKKE ANKTPEINTV IEKSTDFFKK NIVVSGGFVG
     GFLIGLAS