ID   FUD1A_XENLA             Reviewed;         151 AA.
AC   Q58EA0;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=FUN14 domain-containing protein 1A;
GN   Name=fundc1-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as an activator of hypoxia-induced mitophagy, an
CC       important mechanism for mitochondrial quality control. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the FUN14 family. {ECO:0000305}.
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DR   EMBL; BC092015; AAH92015.1; -; mRNA.
DR   RefSeq; NP_001089315.1; NM_001095846.1.
DR   AlphaFoldDB; Q58EA0; -.
DR   DNASU; 734365; -.
DR   GeneID; 734365; -.
DR   KEGG; xla:734365; -.
DR   CTD; 734365; -.
DR   Xenbase; XB-GENE-964326; fundc1.S.
DR   OrthoDB; 1431148at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 734365; Expressed in muscle tissue and 19 other tissues.
DR   GO; GO:0031307; C:integral component of mitochondrial outer membrane; ISS:UniProtKB.
DR   GO; GO:0000422; P:autophagy of mitochondrion; ISS:UniProtKB.
DR   GO; GO:0001666; P:response to hypoxia; ISS:UniProtKB.
DR   InterPro; IPR007014; FUN14.
DR   PANTHER; PTHR21346; PTHR21346; 1.
DR   Pfam; PF04930; FUN14; 1.
PE   2: Evidence at transcript level;
KW   Autophagy; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..151
FT                   /note="FUN14 domain-containing protein 1A"
FT                   /id="PRO_0000271350"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           14..17
FT                   /note="YXXL"
SQ   SEQUENCE   151 AA;  16573 MW;  88E5DEE0BF011E7A CRC64;
     MAARREPSSD DESYEVLDLT DYARRHHWWN RLFGRNSGPL TEKYSVATQI VIGGVSGWCA
     GFLFQKVGKL AATAVGGGFL LLQIASHGGY IQVDWKRVEK DVNNAKRKIK KEANKSAPEI
     NTLIEESTDF VKKNIVVSGG FVGGFLLGLA S