ID   FUCT1_NEMVE             Reviewed;         339 AA.
AC   A7S1L6;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=GDP-fucose transporter 1;
DE   AltName: Full=Solute carrier family 35 member C1 homolog;
GN   Name=slc35c1; Synonyms=fuct1; ORFNames=v1g205399;
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6;
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- FUNCTION: Involved in GDP-fucose import from the cytoplasm into the
CC       Golgi lumen. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TPT transporter family. SLC35C subfamily.
CC       {ECO:0000305}.
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DR   EMBL; DS469565; EDO42347.1; -; Genomic_DNA.
DR   RefSeq; XP_001634410.1; XM_001634360.1.
DR   AlphaFoldDB; A7S1L6; -.
DR   SMR; A7S1L6; -.
DR   STRING; 45351.EDO42347; -.
DR   EnsemblMetazoa; EDO42347; EDO42347; NEMVEDRAFT_v1g205399.
DR   GeneID; 5514196; -.
DR   KEGG; nve:5514196; -.
DR   eggNOG; KOG1442; Eukaryota.
DR   HOGENOM; CLU_044894_1_0_1; -.
DR   InParanoid; A7S1L6; -.
DR   OMA; GLQIKYT; -.
DR   OrthoDB; 870214at2759; -.
DR   PhylomeDB; A7S1L6; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR   GO; GO:0005457; F:GDP-fucose transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0036085; P:GDP-fucose import into Golgi lumen; IBA:GO_Central.
DR   GO; GO:0036066; P:protein O-linked fucosylation; IBA:GO_Central.
DR   InterPro; IPR029666; GDP-fucose_transp.
DR   InterPro; IPR004853; Sugar_P_trans_dom.
DR   PANTHER; PTHR11132:SF255; PTHR11132:SF255; 1.
DR   Pfam; PF03151; TPT; 1.
PE   3: Inferred from homology;
KW   Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..339
FT                   /note="GDP-fucose transporter 1"
FT                   /id="PRO_0000343212"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          319..339
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   339 AA;  37312 MW;  CF3D476DA24C0B6F CRC64;
     MKESLLAKSV RIAAVVAAYW TISISLVFLN KYLLSSPDIK LDAPLFVTWY QCVVTVICLF
     FLSLLGDRYP WIDTFPAFHI KLSVAKQVLP LSAVFVGMIT FNNLCLKNLG VSFYNVGRSL
     TTVFNVICTY VILGQSTSYK AVICCAVIIG GFLMGVDQEG SSGKISYSGV LFGVLASLCV
     SLNAIYTKKF IPAVDNNIWR LQLYNNFNAC FLFLPLMALL GEIGEVAHFP NLSSAYFWLM
     MTIGGVFGIA IGYITGLQIK VTSPLTHNIS GTAKACVQTI MSVSYFHETK TALWWLSNAM
     VLGGSMAYTR VRHSEMKKAH TIQASKDDKA LQEDGQTKV