FUCT1_MOUSE
ID FUCT1_MOUSE Reviewed; 363 AA.
AC Q8BLX4; Q3UMP5; Q8BV24;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=GDP-fucose transporter 1;
DE AltName: Full=Solute carrier family 35 member C1;
GN Name=Slc35c1; Synonyms=Fuct1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, Cerebellum, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Involved in GDP-fucose import from the cytoplasm into the
CC Golgi lumen. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35C subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK040986; BAC30770.1; -; mRNA.
DR EMBL; AK081068; BAC38127.1; -; mRNA.
DR EMBL; AK144762; BAE26053.1; -; mRNA.
DR EMBL; AK151154; BAE30160.1; -; mRNA.
DR EMBL; AL683814; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC116736; AAI16737.1; -; mRNA.
DR EMBL; BC119128; AAI19129.1; -; mRNA.
DR CCDS; CCDS16448.1; -.
DR RefSeq; NP_997597.1; NM_211358.2.
DR AlphaFoldDB; Q8BLX4; -.
DR SMR; Q8BLX4; -.
DR STRING; 10090.ENSMUSP00000063461; -.
DR iPTMnet; Q8BLX4; -.
DR PhosphoSitePlus; Q8BLX4; -.
DR SwissPalm; Q8BLX4; -.
DR MaxQB; Q8BLX4; -.
DR PaxDb; Q8BLX4; -.
DR PRIDE; Q8BLX4; -.
DR ProteomicsDB; 271810; -.
DR Antibodypedia; 13252; 64 antibodies from 20 providers.
DR DNASU; 228368; -.
DR Ensembl; ENSMUST00000067631; ENSMUSP00000063461; ENSMUSG00000049922.
DR GeneID; 228368; -.
DR KEGG; mmu:228368; -.
DR UCSC; uc008kyb.1; mouse.
DR CTD; 55343; -.
DR MGI; MGI:2443301; Slc35c1.
DR VEuPathDB; HostDB:ENSMUSG00000049922; -.
DR eggNOG; KOG1442; Eukaryota.
DR GeneTree; ENSGT00390000013315; -.
DR InParanoid; Q8BLX4; -.
DR OMA; GLQIKYT; -.
DR OrthoDB; 870214at2759; -.
DR PhylomeDB; Q8BLX4; -.
DR TreeFam; TF354269; -.
DR Reactome; R-MMU-6787639; GDP-fucose biosynthesis.
DR Reactome; R-MMU-727802; Transport of nucleotide sugars.
DR BioGRID-ORCS; 228368; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Slc35c1; mouse.
DR PRO; PR:Q8BLX4; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BLX4; protein.
DR Bgee; ENSMUSG00000049922; Expressed in dorsal pancreas and 219 other tissues.
DR ExpressionAtlas; Q8BLX4; baseline and differential.
DR Genevisible; Q8BLX4; MM.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0005457; F:GDP-fucose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0036085; P:GDP-fucose import into Golgi lumen; IBA:GO_Central.
DR GO; GO:0030259; P:lipid glycosylation; IMP:MGI.
DR GO; GO:0045746; P:negative regulation of Notch signaling pathway; IMP:MGI.
DR GO; GO:0036066; P:protein O-linked fucosylation; IBA:GO_Central.
DR InterPro; IPR029666; GDP-fucose_transp.
DR InterPro; IPR004853; Sugar_P_trans_dom.
DR PANTHER; PTHR11132:SF255; PTHR11132:SF255; 1.
DR Pfam; PF03151; TPT; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..363
FT /note="GDP-fucose transporter 1"
FT /id="PRO_0000343221"
FT TRANSMEM 33..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 226..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 43
FT /note="V -> G (in Ref. 1; BAC38127)"
FT /evidence="ECO:0000305"
FT CONFLICT 110
FT /note="L -> V (in Ref. 1; BAE26053)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 363 AA; 39967 MW; A298B2E9E4DD26D1 CRC64;
MNRAPLKRSR ILRMALTGVS AVSEESESGN KPFLLRALQI ALVVSLYWVT SISMVFLNKY
LLDSPSLQLD TPIFVTFYQC LVTSLLCKGL STLATCCPGM VDFPTLNLDL KVARSVLPLS
VVFIGMITFN NLCLKYVGVP FYNVGRSLTT VFNVLLSYLL LKQTTSFYAL LTCGVIIGGF
WLGIDQEGAE GTLSLTGTIF GVLASLCVSL NAIYTKKVLP AVDHSIWRLT FYNNVNACVL
FLPLMIVLGE LRALLAFTHL SSAHFWLMMT LGGLFGFAIG YVTGLQIKFT SPLTHNVSGT
AKACAQTVLA VLYYEEIKSF LWWTSNLMVL GGSSAYTWVR GWEMQKTQED PSSKDGEKSA
IRV
