FUCT1_DICDI
ID FUCT1_DICDI Reviewed; 368 AA.
AC Q550W6; Q86KQ3;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=GDP-fucose transporter 1;
DE AltName: Full=Solute carrier family 35 member C1 homolog;
GN Name=slc35c1; Synonyms=fuct1; ORFNames=DDB_G0277007;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Involved in GDP-fucose import from the cytoplasm into the
CC Golgi lumen. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TPT transporter family. SLC35C subfamily.
CC {ECO:0000305}.
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DR EMBL; AAFI02000019; EAL69005.1; -; Genomic_DNA.
DR RefSeq; XP_642816.1; XM_637724.1.
DR AlphaFoldDB; Q550W6; -.
DR SMR; Q550W6; -.
DR STRING; 44689.DDB0217856; -.
DR PaxDb; Q550W6; -.
DR EnsemblProtists; EAL69005; EAL69005; DDB_G0277007.
DR GeneID; 8620679; -.
DR KEGG; ddi:DDB_G0277007; -.
DR dictyBase; DDB_G0277007; -.
DR eggNOG; KOG1442; Eukaryota.
DR HOGENOM; CLU_044894_1_0_1; -.
DR InParanoid; Q550W6; -.
DR OMA; MYYTWVK; -.
DR PhylomeDB; Q550W6; -.
DR Reactome; R-DDI-6787639; GDP-fucose biosynthesis.
DR Reactome; R-DDI-727802; Transport of nucleotide sugars.
DR PRO; PR:Q550W6; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0005457; F:GDP-fucose transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0036085; P:GDP-fucose import into Golgi lumen; IBA:GO_Central.
DR GO; GO:0036066; P:protein O-linked fucosylation; IBA:GO_Central.
DR InterPro; IPR029666; GDP-fucose_transp.
DR InterPro; IPR004853; Sugar_P_trans_dom.
DR PANTHER; PTHR11132:SF255; PTHR11132:SF255; 1.
DR Pfam; PF03151; TPT; 1.
PE 3: Inferred from homology;
KW Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..368
FT /note="GDP-fucose transporter 1"
FT /id="PRO_0000343210"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..352
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 368 AA; 41466 MW; FBE62CE9F9B59371 CRC64;
MNIQNDKERL LNGSIDEIEI ITTDNNENDT IRNDDILKNS QLREQQQHQQ IQQQIQQQKK
ESSLSTIASV IAFYFFISIS LVFLNKILLS DFKFEYPLFI TWYQQIISFV SIYIMTSISK
SVPALSFLPE FEFKSATASK VLPVTAVLTG MVIFNNLCLE YVEVSFYQVA RSLTICFSLI
LTYIVLKSKT SYRATMACLV VFLGFVLGSA GEVNFSWLGI IFGLLSSFFV ALYSIAVKRV
LPAVDGNEWR LSIYNTAISI GLIFPLILVS GEANTILDEP LLYSGTFWFY MTVAGLMGYL
ISISVFMQIK HTSPLTNTIS GTVKACVQTI LAVVFWGNPI STQNAVGILL VIGGSFWYSM
QRFFEMKK
