ID   FUCT1_BOVIN             Reviewed;         364 AA.
AC   A6QM03;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=GDP-fucose transporter 1;
DE   AltName: Full=Solute carrier family 35 member C1;
GN   Name=SLC35C1; Synonyms=FUCT1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in GDP-fucose import from the cytoplasm into the
CC       Golgi lumen. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TPT transporter family. SLC35C subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC148149; AAI48150.1; -; mRNA.
DR   RefSeq; NP_001094680.1; NM_001101210.2.
DR   AlphaFoldDB; A6QM03; -.
DR   SMR; A6QM03; -.
DR   STRING; 9913.ENSBTAP00000041834; -.
DR   PaxDb; A6QM03; -.
DR   Ensembl; ENSBTAT00000085203; ENSBTAP00000070442; ENSBTAG00000003199.
DR   GeneID; 540413; -.
DR   KEGG; bta:540413; -.
DR   CTD; 55343; -.
DR   VEuPathDB; HostDB:ENSBTAG00000003199; -.
DR   VGNC; VGNC:34827; SLC35C1.
DR   eggNOG; KOG1442; Eukaryota.
DR   GeneTree; ENSGT00390000013315; -.
DR   HOGENOM; CLU_044894_1_0_1; -.
DR   InParanoid; A6QM03; -.
DR   OMA; GLQIKYT; -.
DR   OrthoDB; 870214at2759; -.
DR   TreeFam; TF354269; -.
DR   Proteomes; UP000009136; Chromosome 15.
DR   Bgee; ENSBTAG00000003199; Expressed in abomasum and 103 other tissues.
DR   ExpressionAtlas; A6QM03; baseline and differential.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR   GO; GO:0005457; F:GDP-fucose transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0036085; P:GDP-fucose import into Golgi lumen; IBA:GO_Central.
DR   GO; GO:0030259; P:lipid glycosylation; IEA:Ensembl.
DR   GO; GO:0045746; P:negative regulation of Notch signaling pathway; IEA:Ensembl.
DR   GO; GO:0036066; P:protein O-linked fucosylation; IBA:GO_Central.
DR   InterPro; IPR029666; GDP-fucose_transp.
DR   InterPro; IPR004853; Sugar_P_trans_dom.
DR   PANTHER; PTHR11132:SF255; PTHR11132:SF255; 1.
DR   Pfam; PF03151; TPT; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..364
FT                   /note="GDP-fucose transporter 1"
FT                   /id="PRO_0000343222"
FT   TRANSMEM        34..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          345..364
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   364 AA;  40005 MW;  465B2E1474FD2927 CRC64;
     MNRASLKRSK ILHMALMGTS DPSGEAEASQ EKPFVLRALQ IALVVSLYWV TSISMVFLNK
     YLLDSPSLRL DTPIFVTFYQ CLVTVLLCKG LSSLATCCPG TVDFPALHLD LKVARSVLPL
     SVVFIGMITF NNLCLKYVGV AFYNVGRSLT TVFNVLLSYL LLKQTTSFYA LLTCSVIIGG
     FWLGVDQEGA EGTLSWTGTL FGVLASLCVS LNAIYTKKVL PAVDGSIWRL TFYNNANACV
     LFLPLLLALG ELRALLAFPQ LGSAHFWAMM TLGGLFGFAI GYVTGLQIKF TSPLTHNVSG
     TAKACAQTVL AVLYYEEAKS FLWWTSNMMV LGGSSAYTWV RGREMKKTQE EPHPRENEKS
     NMEV