ID   FUCR_SHIFL              Reviewed;         243 AA.
AC   P0ACK9; P11554;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=L-fucose operon activator;
GN   Name=fucR; OrderedLocusNames=SF2819, S3014;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Transcriptional activator of the fuc operon. {ECO:0000250}.
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DR   EMBL; AE005674; AAN44306.2; -; Genomic_DNA.
DR   EMBL; AE014073; AAP18131.1; -; Genomic_DNA.
DR   RefSeq; NP_708599.2; NC_004337.2.
DR   RefSeq; WP_000642344.1; NZ_WPGW01000008.1.
DR   AlphaFoldDB; P0ACK9; -.
DR   SMR; P0ACK9; -.
DR   STRING; 198214.SF2819; -.
DR   EnsemblBacteria; AAN44306; AAN44306; SF2819.
DR   EnsemblBacteria; AAP18131; AAP18131; S3014.
DR   GeneID; 1025822; -.
DR   GeneID; 66673328; -.
DR   KEGG; sfl:SF2819; -.
DR   KEGG; sfx:S3014; -.
DR   PATRIC; fig|198214.7.peg.3356; -.
DR   HOGENOM; CLU_060699_1_2_6; -.
DR   OMA; YKHSMVA; -.
DR   OrthoDB; 1629121at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006004; P:fucose metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR014036; DeoR_C.
DR   InterPro; IPR001034; DeoR_HTH.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR018356; Tscrpt_reg_HTH_DeoR_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00455; DeoRC; 1.
DR   Pfam; PF08220; HTH_DeoR; 1.
DR   PRINTS; PR00037; HTHLACR.
DR   SMART; SM00420; HTH_DEOR; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00894; HTH_DEOR_1; 1.
DR   PROSITE; PS51000; HTH_DEOR_2; 1.
PE   3: Inferred from homology;
KW   Activator; Carbohydrate metabolism; DNA-binding; Fucose metabolism;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..243
FT                   /note="L-fucose operon activator"
FT                   /id="PRO_0000050248"
FT   DOMAIN          1..57
FT                   /note="HTH deoR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
FT   DNA_BIND        19..38
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
SQ   SEQUENCE   243 AA;  27362 MW;  3DFBBD33E7E64296 CRC64;
     MKAARQQAIV DLLLNHTSLT TEALSEQLKV SKETIRRDLN ELQTQGKILR NHGRAKYIHR
     QNQDSGDPFH IRLKSHYAHK ADIAREALAW IEEGMVIALD ASSTCWYLAR QLPDINIQVF
     TNSHPICHEL GKRERIQLIS SGGTLERKYG CYVNPSLISQ LKSLEIDLFI FSCEGIDSSG
     ALWDSNAINA DYKSMLLKRA AQSLLLIDKS KFNRSGEARI GHLDEVTHII SDERQVATSL
     VTA