ID   FUCR_HAEIN              Reviewed;         249 AA.
AC   P44780;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=L-fucose operon activator;
GN   Name=fucR; OrderedLocusNames=HI_0615;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Transcriptional activator of the fuc operon. {ECO:0000250}.
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DR   EMBL; L42023; AAC22274.1; -; Genomic_DNA.
DR   PIR; G64081; G64081.
DR   RefSeq; NP_438773.1; NC_000907.1.
DR   RefSeq; WP_005661551.1; NC_000907.1.
DR   AlphaFoldDB; P44780; -.
DR   SMR; P44780; -.
DR   STRING; 71421.HI_0615; -.
DR   DNASU; 949664; -.
DR   EnsemblBacteria; AAC22274; AAC22274; HI_0615.
DR   KEGG; hin:HI_0615; -.
DR   PATRIC; fig|71421.8.peg.639; -.
DR   eggNOG; COG1349; Bacteria.
DR   HOGENOM; CLU_060699_1_2_6; -.
DR   OMA; YKHSMVA; -.
DR   PhylomeDB; P44780; -.
DR   BioCyc; HINF71421:G1GJ1-636-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006004; P:fucose metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR014036; DeoR_C.
DR   InterPro; IPR001034; DeoR_HTH.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR018356; Tscrpt_reg_HTH_DeoR_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00455; DeoRC; 1.
DR   Pfam; PF08220; HTH_DeoR; 1.
DR   PRINTS; PR00037; HTHLACR.
DR   SMART; SM00420; HTH_DEOR; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00894; HTH_DEOR_1; 1.
DR   PROSITE; PS51000; HTH_DEOR_2; 1.
PE   3: Inferred from homology;
KW   Activator; Carbohydrate metabolism; DNA-binding; Fucose metabolism;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..249
FT                   /note="L-fucose operon activator"
FT                   /id="PRO_0000050249"
FT   DOMAIN          1..56
FT                   /note="HTH deoR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
FT   DNA_BIND        18..37
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00349"
SQ   SEQUENCE   249 AA;  28163 MW;  AAA07C53B1965714 CRC64;
     MNYRDELILQ WVNQQGKASV IELAQHCDIS VETIRRDLNK LANKGLLHRT HGGAVSNKTK
     DLGSFFQTRK HINATAKRHI AQKALDLLYE NAVIGLDASS TSWYFAYLMP DIPCTVVTNS
     MFNINALVNK SNVKTIVTGG VYSAKYEAFY GPLSEYLLQR LHINFSVFSC SGIDKNGNIW
     ESNELNASLK RKMMEASERA YLLIDSSKFE KTSLIQLADL SKINTIFSDR SLPDNLQKYC
     EQHDIMTVL